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Category: biotech/medical – Page 1,239

Aging, Environment and Genetics: Which Is More Important for Regulating Gene Expression?

Amid much speculation and research about how our genetics affect the way we age, a University of California, Berkeley, study now shows that individual differences in our DNA matter less as we get older and become prone to diseases of aging, such as diabetes and cancer.

In a study of the relative effects of genetics, aging and the environment on how some 20,000 human genes are expressed, the researchers found that aging and environment are far more important than genetic variation in affecting the expression profiles of many of our genes as we get older. The level at which genes are expressed — that is, ratcheted up or down in activity — determines everything from our hormone levels and metabolism to the mobilization of enzymes that repair the body.

“How do your genetics — what you got from your sperm donor and your egg donor and your evolutionary history — influence who you are, your phenotype, such as your height, your weight, whether or not you have heart disease?” said Peter Sudmant, UC Berkeley assistant professor of integrative biology and a member of the campus’s Center for Computational Biology. “There’s been a huge amount of work done in human genetics to understand how genes are turned on and off by human genetic variation. Our project came about by asking, ‘How is that influenced by an individual’s age?’ And the first result we found was that your genetics actually matter less the older you get.”

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Engineers create a computer with a water droplet processor

Circa 2015 face_with_colon_three

From driving water wheels to turning turbines, waterhas been used as the prime mover of machinery and the powerhouse of industry for many centuries. In ancient times, the forces of flowing water were even harnessed to power the first rudimentaryclocks. Now, engineers at Stanford University have created the world’s first water-operated computer. Using magnetized particles flowing through a micro-miniature network ofchannels, the machine runs like clockwork and is claimed to be capable ofperforming complex logical operations.

Using poppy-seed sizeddroplets of water impregnated with magnetic nanoparticles (those handy little elementsbeing used in everything from drug delivery inhumans to creating e-paper whiteboards), the new fluidic computer uses electromagnetic fields to accurately pump thesedroplets around a set of physical gates to perform logical operations. Suspendedin oil and timed to move in very specific steps, the droplets in the system cantheoretically be used to accomplish any process that a normal electroniccomputer can, albeit at considerably slower speeds.

Stanford assistant professor Manu Prakash has spent almost a decadethinking about such a device, ever since he was a graduate student. The manyand varied components required of a fluidic computer have slowly coalesced inhis mind over that time, with the most fundamental component of all – an accurateoperating clock to drive the logic – being the crucial element in bringing hisinvention to fruition. Ultimately, Prakash built a rotating magnetic field to synchronize the flow of all the droplets in a precisely timed manner, andact as the clock.

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Porphyromonas gingivalis Conditioned Medium Induces Amyloidogenic Processing of the Amyloid-β Protein Precursor upon in vitro Infection of SH-SY5Y Cells

Researchers at the School of Dentistry, University of Central Lancashire (UCLan) were the first to report the link between gum disease and Alzheimer’s disease. Now two new studies from the same research group at the School of Dentistry demonstrate that progress is being made in making much stronger connections between gum disease in the mouth and deteriorating brain function.

Abstract: Journal of Alzheimer’s Disease.

Antimicrobial, Polarizing Light, and Paired Helical Filament Properties of Fragmented Tau Peptides of Selected Putative Gingipains https://content.iospress.com/articles/journal-of-alzheimers-disease/jad220486

Abstract: journal of alzheimer’s disease reports.

Porphyromonas gingivalis Conditioned Medium Induces Amyloidogenic Processing of the Amyloid-β Protein Precursor upon in vitro Infection of SH-SY5Y Cells.

#gumdisease #science #brain #neuroscience #dentist #dentistry #alzheimersawareness #alzheimersdisease #alzheimer #gingivitis #tau #plaques #nervecell

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An Unlikely Source Provides New Hope for Heart Disease Patients

Time halted during the European Football Championship last summer. When football player Christian Eriksen unexpectedly fell, passed away, and was resuscitated on live television, the buzzing anxiety that had filled the air vanished in a matter of seconds. And in no time, millions of people all over the globe were aware of the danger posed by cardiovascular diseases, the leading cause of mortality in the western world, according to the World Health Organization.

When the heart fails in young athletes, the condition ARVC is often to blame. Half of all cases of sudden cardiac arrest in athletes occurring during physical activity are thought to be caused by ARVC.

Researchers from the University of Copenhagen provide new insights into a process involved in the development of the disease in a recent study. In fact, they also present a viable treatment method, according to Professor Alicia Lundby, whose research team led the new study.

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Combination of Rapamycin and Acarbose Extends Lifespan

28 to 34% lifespan increase in mice. I wonder if there would be side effects as a recent study showed Rapamycin and Metformin canceled each other’s side effects.

In a new study published in Aging Cell, researchers have tested several individual drugs and a combination of rapamycin plus acarbose as potential life extension agents in genetically heterogeneous mice [1].

Identification of successful anti-aging interventions is arguably one of the most challenging research problems to date. In addition to the complexity of aging, researchers have to deal with the biological heterogeneity of animals even within the same species and research reproducibility issues due to different experimental designs and approaches.

The National Institute on Aging Interventions Testing Program (ITP) was launched in 2004 with these limitations in mind. It is a peer-reviewed multi-institutional study evaluating potential lifespan-extending agents. The experiments are run in parallel at the Jackson Laboratory; the University of Michigan; and the University of Texas Health Science Center at San Antonio on genetically heterogeneous mice of both sexes.

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Scientists found going to bed before 9 p.m. has a 70% higher risk of developing dementia

So early to bed early to rise does not necessarily make a person healthy wealthy and wise.

In a recent study, scientists found early sleeping had a 70% higher risk of developing dementia.

Sleep may impact both physical and mental health and has been linked to various health conditions such as heart disease, stroke, dementia, depression, and obesity.

On September 21, researchers published a study in the Journal of the American Geriatrics Society, which shows early sleeping had a 70% higher risk of developing dementia and cognitive decline.

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