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Category: biotech/medical – Page 1,232

“Harms in early life can take many forms, and can lead to health consequences many years down the road. What our study shows is that these consequences manifest as perturbations to multiple biological systems, which can be measured from biomarkers in blood.”…

Individuals exposed to adverse childhood experiences tend to be biologically older than their counterparts, according to new research published in the scientific journal Psychoneuroendocrinology.

Adverse childhood experiences refer to a set of potentially traumatic events that occur before adulthood. These experiences include various forms of abuse and neglect, witnessing intimate partner violence, parental death or serious illness, parental divorce or separation, and psychiatric illness of a family member. Biological aging, on the other hand, refers to the accumulation of damage and loss of function to cells, tissues and organs.

Previous research has found that people exposed to adverse childhood experiences are more likely to suffer from chronic diseases and have a shorter lifespan. The authors of the new study were interested in whether accelerated biological aging could help explain the relationship between adverse childhood experiences and poor health outcomes later in life.

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Tech major Google is reportedly slowing down its hiring processes for the rest of 2022. According to a memo by CEO Sundar Pichai to employees, obtained by The Verge, Google will still support its “most important opportunities”, and focus on hiring engineering, technical and other critical roles.

Until now, Google has remained relatively immune to economic uncertainties, and in fact, its sister brand YouTube did well in Q4 2020 — first year of the Covid-19 pandemic. It was reported that its ad revenue hit $6.9 billion — up by 46% quarter-on-quarter. Pichai, in his memo, also highlights that the company hired approximately 10,000 employees in the second quarter of this year, and has a “number of commitments for Q3”, Pichai said in the memo adding that “Google will pause the hiring process for the rest of the year”.

“For the balance of 2022 and 2023, we’ll focus our hiring on engineering, technical and other critical roles, and make sure the great talent we do hire is aligned with our long-term priorities,” he reportedly wrote in the memo.

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An international team of physicists has developed a new technique that allows researchers to study the interactions between neutrons inside of an atom. In their paper published in the journal Nature, the group describe their laser spectroscopy measurement technique and how it can be used.

It has been nearly 100 years since scientists discovered that inside of every atom are —which give atoms their —as well as . And despite much study of subatomic particles, scientists still do not know what sorts of interactions go on inside of an atom. In this new effort, the researchers modified laser spectroscopy measurement techniques to study such interactions.

In this new work, the researchers began by looking at elements with a —those that have highly stable protons and neutrons—and wound up using indium-131, which has a magic number of neutrons, and also a proton hole, in which a nuclide has one fewer proton than a traditional magic number element. Indium-131 is, unfortunately, also notoriously unstable, which means that it only exists for a short time before breaking down—it tends to last for just 0.28 seconds.

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The question of how the chemical composition of a protein—the amino acid sequence—determines its 3D structure has been one of the biggest challenges in biophysics for more than half a century. This knowledge about the so-called “folding” of proteins is in great demand, as it contributes significantly to the understanding of various diseases and their treatment, among other things. For these reasons, Google’s DeepMind research team has developed AlphaFold, an artificial intelligence that predicts 3D structures.

A team consisting of researchers from Johannes Gutenberg University Mainz (JGU) and the University of California, Los Angeles, has now taken a closer look at these structures and examined them with respect to knots. We know knots primarily from shoelaces and cables, but they also occur on the nanoscale in our cells. Knotted proteins can not only be used to assess the quality of structure but also raise important questions about folding mechanisms and the evolution of proteins.

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By Subscription? – In California, You Can and it’s a Tesla Model 3 EV.

A Santa Monica, California-based company can put you into a Tesla Model 3 using its cellphone app which is now available for both Android and iPhones. The company offering the Car-as-a-service (CaaS) model is Autonomy. Although currently available only in California, the future plans include rolling it out to other U.S. states.

Until the outset of the global pandemic, owning a car was on a dramatic decline. Ride-sharing was exploding, and because cars were becoming pricier, young people entering the workforce were less inclined to join their parents’ generation of car owners.

Isolation and lockdowns temporarily took drivers off the road, as did sticker shock. The latter has been particularly true for electric vehicles (EV) which without government rebates and incentives can cost tens of thousands of dollars more than cars running on gasoline and diesel.

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Hibernation Biology & Applications In Human Health & Resilience — Dr. Dana K. Merriman, Ph.D., Distinguished Professor Emerita of Biology; Director of the Squirrel Colony, UW-Oshkosh.

Dr. Dana K. Merriman Ph.D. (www.uwosh.edu/facstaff/merriman/VaughanHome), is Distinguished Professor Emerita of Biology, and Director of the Squirrel Colony, at University of Wisconsin Oshkosh, and Adjunct Professor of Ophthalmology & Visual Sciences, Medical College of Wisconsin.

With her BA in Biological Science and her PhD in Physiology and Cell Biology, both from University of California-Santa Barbara, as well as having spent time as a Postdoctoral Fellow at University of Utah Health Sciences Center, a core focus of Dr. Merriman’s laboratory research over the years has been the development of a captive breeding colony of the 13-lined ground squirrels.

This unique, one-of-a-kind captive breeding program, due to this species very unique cone-dominant, diurnal visual system, as well as their impressive physiological ability to survive in hibernation for over six months without food or water, has served investigators with animals and custom-dissected tissues from the US, Asia, and Europe for decades, as well as been core to Dr Merriman’s own work on vision, including cone cell biology and retinal function during the metabolic state transitions associated with hibernation.

Over the years, Dr. Merriman expanded her research horizon well outside of vision, into neuroscience, and in recent years she has collaborated on studies of muscle physiology, viral genomics, molecular biology of transposable elements, and comparative genetics of the control of coat patterning.

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Research that was recently published in Scientific Reports presents the first human genome that has been successfully sequenced from a person who passed away in Pompeii, Italy, after Mount Vesuvius’ explosion in the year 79 CE. Only little segments of mitochondrial DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

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High-performance, micro-sized electrochemical energy storage devices are essential for future miniaturized electronic devices, such as smart medical implants, wireless sensors, and the Internet of Things. Microbatteries (MBs) typically show higher energy density and more stable voltage output than micro-supercapacitors.

However, current MBs involve tedious construction procedures and unsatisfactory electrochemical performance. In addition, no methods exist to construct or manipulate a liquid microelectrode.

A joint research team led by Prof. Qu Liangti from Tsinghua University, Prof. Zhang Zhipan from the Beijing Institute of Technology, and Prof. Liu Feng from the Institute of Mechanics of the Chinese Academy of Sciences (IMCAS) recently proposed a dual-plating strategy to rapidly construct new zinc–bromine microbatteries (Zn–Br2 MBs) with ultrahigh areal and polarity-switchable functionality.

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Ritu Raman leads the Raman Lab, where she creates adaptive biological materials for applications in medicine and machines.

It seems that Ritu Raman was born with an aptitude for engineering. You may say it is in her blood since her mother is a chemical engineer, her father is a mechanical engineer, and her grandfather is a civil engineer. Throughout her childhood, she repeatedly witnessed firsthand the beneficial impact that engineering careers could have on communities. In fact, watching her parents build communication towers to connect the rural villages of Kenya to the global infrastructure is one of her earliest memories. She still vividly remembers the excitement she felt watching the emergence of a physical manifestation of innovation that would have a long-lasting positive impact on the community.

Raman is “a mechanical engineer through and through,” as she puts it. She earned her BS, MS, and PhD in mechanical engineering. Her postdoctoral work at MIT.

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Cancer researchers have discovered how mutated cells can sense the Goldilocks sweet spots in a human body.

Led by the University of Minnesota Twin Cities, an international group of researchers has shed new light on how cancer thrives.

Previous studies have shown how cancer cells can sense the stiffness of the environment they are in, from hard bone and tough muscle to soft, fatty tissue.

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