Lifeboat Foundation

New probes allow scientists to see four-stranded DNA interacting with molecules inside living human cells, unraveling its role in cellular processes.

DNA usually forms the classic double helix shape of two strands wound around each other. While DNA can form some more exotic shapes in test tubes, few are seen in real living cells.

However, four-stranded DNA, known as G-quadruplex, has recently been seen forming naturally in human cells. Now, in new research published today in Nature Communications, a team led by Imperial College London scientists have created new probes that can see how G-quadruplexes are interacting with other molecules inside living cells.

At the more advanced end of things, genetic modifications and advanced medical procedures might be available in the future that can restore muscle tissue, bone density, and organ health. If such treatments are available down the road, periodic visits to the doctor could allow Loonies to live happy and healthy lives in lower gravity.

In so many ways, a permanent human presence on the Moon could open the door to the entire Solar System. With the ability to refuel and resupply missions from a lunar site, space agencies could shave billions off the cost of deep-space missions. It would also facilitate missions to Mars, Venus, the Asteroid Belt, and beyond.

Cellular senescence, a state of permanent growth arrest, has emerged as a hallmark and fundamental driver of organismal aging. It is regulated by both genetic and epigenetic factors. Despite a few previously reported aging-associated genes, the identity and roles of additional genes involved in the regulation of human cellular aging remain to be elucidated. Yet, there is a lack of systematic investigation on the intervention of these genes to treat aging and aging-related diseases.

How many aging-promoting genes are there in the human genome? What are the molecular mechanisms by which these genes regulate aging? Can gene therapy alleviate individual aging? Recently, researchers from the Chinese Academy of Sciences have shed new light on the regulation of aging.

Recently, researchers from the Institute of Zoology of the Chinese Academy of Sciences (CAS), Peking University, and Beijing Institute of Genomics of CAS have collaborated to identify new human senescence-promoting genes by using a genome-wide CRISPR/Cas9 screening system and provide a new therapeutic approach for treating aging and aging-related pathologies.

Lawrence Livermore National Laboratory (LLNL) researchers have discovered that carbon nanotube membrane pores could enable ultra-rapid dialysis processes that would greatly reduce treatment time for hemodialysis patients.

The ability to separate molecular constituents in complex solutions is crucial to many biological and man-made processes. One way is via the application of a concentration gradient across a porous membrane. This drives ions or molecules smaller than the pore diameters from one side of the membrane to the other while blocking anything that is too large to fit through the pores.

In nature, biological membranes such as those in the kidney or liver can perform complex filtrations while still maintaining high throughput. Synthetic membranes, however, often struggle with a well-known trade-off between selectivity and permeability. The same material properties that dictate what can and cannot pass through the membrane inevitably reduce the rate at which filtration can occur.

Summary: Using data from RNA sequencing, researchers have identified three molecular subtypes of Alzheimer’s disease.

Source: Mount Sinai Hospital.

Researchers at the Icahn School of Medicine at Mount Sinai have identified three major molecular subtypes of Alzheimer’s disease (AD) using data from RNA sequencing. The study advances our understanding of the mechanisms of AD and could pave the way for developing novel, personalized therapeutics.

Gene-editing method shows promise for premature aging syndrome.

Scientists have fixed a genetic mutation in mice with progeria, a rapid aging disease. The treatment could one day be used in humans who would otherwise die in childhood.

Approximately 1 in 4 million children are diagnosed with progeria within the first two years of birth, and virtually all of these children develop health issues in childhood and adolescence that are normally associated with old age – including cardiovascular disease (heart attacks and strokes), hair loss, skeletal problems, subcutaneous fat loss and hardened skin.

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Continue reading “How the tangles in your DNA make you age” »

Every year, over a million people develop health care-acquired infections during their hospital stays. And around 100000 of them die from those complications.

But researchers at the University of Georgia are determined to change that, and their new study shows a promising tool for preventing infections before they happen.

Continue reading “Building safer medical devices with innovative protective nanoparticle coating” »