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Category: biotech/medical – Page 1,212

28 to 34% lifespan increase in mice. I wonder if there would be side effects as a recent study showed Rapamycin and Metformin canceled each other’s side effects.

In a new study published in Aging Cell, researchers have tested several individual drugs and a combination of rapamycin plus acarbose as potential life extension agents in genetically heterogeneous mice [1].

Identification of successful anti-aging interventions is arguably one of the most challenging research problems to date. In addition to the complexity of aging, researchers have to deal with the biological heterogeneity of animals even within the same species and research reproducibility issues due to different experimental designs and approaches.

The National Institute on Aging Interventions Testing Program (ITP) was launched in 2004 with these limitations in mind. It is a peer-reviewed multi-institutional study evaluating potential lifespan-extending agents. The experiments are run in parallel at the Jackson Laboratory; the University of Michigan; and the University of Texas Health Science Center at San Antonio on genetically heterogeneous mice of both sexes.

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So early to bed early to rise does not necessarily make a person healthy wealthy and wise.

In a recent study, scientists found early sleeping had a 70% higher risk of developing dementia.

Sleep may impact both physical and mental health and has been linked to various health conditions such as heart disease, stroke, dementia, depression, and obesity.

On September 21, researchers published a study in the Journal of the American Geriatrics Society, which shows early sleeping had a 70% higher risk of developing dementia and cognitive decline.

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Continue reading “Improve Lung Function, Reduce Blood Pressure, Slow Brain Aging?” | >

The users can effectively manipulate the prosthetics exactly like they would with an intact limb.

University of Utah researchers have developed the most advanced AI-powered prosthetics “ever created,” prompting Ottobock, the world’s largest prosthetic manufacturer, to collaborate with them to launch the project globally.

“Our @LabBionic [Bionic engineering lab] has developed the “Utah Bionic Leg,” the most advanced bionic leg ever created. Now, we’ve forged a partnership with the worldwide leader in the prosthetics industry, @OttobockUK, to bring it to individuals with lower-limb amputations,” the university’s official account tweeted on Friday.

The University of Utah has developed the most advanced AI-powered prosthetics “ever created,” prompting Ottobock, the world’s largest prosthetic manufacturer, to collaborate with them to launch the project globally.

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While CommonSpirit declined to share specifics, a person familiar with its remediation efforts confirmed to NBC News that it had sustained a ransomware attack.

CommonSpirit, which has more than 140 hospitals in the U.S., also declined to share information on how many of its facilities were experiencing delays. Multiple hospitals, however, including CHI Memorial Hospital in Tennessee, some St. Luke’s hospitals in Texas, and Virginia Mason Franciscan Health in Seattle all have announced they were affected.

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Glia, a non-excitable cell type once considered merely as the connective tissue between neurons, is nowadays acknowledged for its essential contribution to multiple physiological processes including learning, memory formation, excitability, synaptic plasticity, ion homeostasis, and energy metabolism. Moreover, as glia are key players in the brain immune system and provide structural and nutritional support for neurons, they are intimately involved in multiple neurological disorders. Recent advances have demonstrated that glial cells, specifically microglia and astroglia, are involved in several neurodegenerative diseases including Amyotrophic lateral sclerosis (ALS), Epilepsy, Parkinson’s disease (PD), Alzheimer’s disease (AD), and frontotemporal dementia (FTD). While there is compelling evidence for glial modulation of synaptic formation and regulation that affect neuronal signal processing and activity, in this manuscript we will review recent findings on neuronal activity that affect glial function, specifically during neurodegenerative disorders. We will discuss the nature of each glial malfunction, its specificity to each disorder, overall contribution to the disease progression and assess its potential as a future therapeutic target.

Glia are non-neuronal cells of the nervous system which do not generate electrical impulses yet communicate via other means such as calcium signals. Due to their lack of electrical activity, it was previously assumed that glial cells primarily functioned as “nerve-glue” (Virchow, 1860) and performed house-keeping functions for neurons; however, this concept has shifted due to recent findings showing glia are key components in many neuronal functions that go far beyond housekeeping (Araque et al., 1999; Buskila et al., 2019a).

Glial cells are categorized into two main groups; macroglia, which includes astrocytes, oligodendrocytes, NG2-glia and ependymal cells, and microglia which are the resident phagocytes of the central nervous system (CNS). Each population of glial cells is specialized for a particular function in the central or peripheral nervous system (García-Cabezas et al., 2016), and normal brain function depends on the interplay between neurons and the various types of glial cells. In this review, we will focus on astrocytes and microglia.

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This technique involves having participants place their finger over the camera and flash of a smartphone, which uses a deep-learning algorithm to decipher the blood oxygen levels from the blood flow patterns in the resulting video.

Conditions like asthma or COVID-19 make it harder for bodies to absorb oxygen from the lungs. This leads to oxygen saturation percentages dropping to 90% or below, indicating that medical attention is needed.

In a clinic, doctors monitor oxygen saturation using pulse oximeters — those clips you put over your fingertip or ear. But monitoring oxygen saturation at home multiple times a day could help patients keep an eye on COVID symptoms, for example.

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Dr. Amy Proal, Ph.D. serves as President & CEO of the PolyBio Research Foundation (https://polybio.org/), and Chief Scientific Officer of the Long Covid Research Initiative (LCRI — https://lc19.org/).

In her work with PolyBio Research Foundation and the LCRI, Dr. Proal conceptualizes and coordinates large-scale collaborative research projects among research teams studying infection-associated chronic conditions such as Long Covid, Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) and Long Lyme.

Dr. Proal has written multiple review articles that delineate core biological drivers of both the Long Covid and ME/CFS disease processes. She is a regular speaker at infection-associated chronic disease conferences including IACFS/ME, Lyme Mind and The International Congress on Autoimmunity.

Dr. Proal holds a Bachelors of Science in biology from Georgetown University and a Ph.D. in microbiology from Murdoch University in Australia. Her work examines the molecular mechanisms by which viral, bacterial, and fungal pathogens dysregulate human gene expression, immunity, and metabolism, and how dysbiosis of the human microbiome, and/or the human virome, can contribute to chronic inflammatory disease processes.

As a member of the research team at Autoimmunity Research Foundation, Dr. Proal has authored papers and written book chapters for organizations like the J. Craig Venter Institute and The Autoimmunity Network, and lectured at the NIH and numerous USA/international conferences.

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Dr. Sarita A. Mohanty, MD, MPH, MBA (https://www.thescanfoundation.org/about/board-of-directors/sarita-a-mohanty/), serves as the President and Chief Executive Officer of The SCAN Foundation, one of the largest foundations in the United States focused on improving the quality of health and life for older adults. Its mission is to advance a coordinated and easily navigated system of high-quality services for older adults that preserve dignity and independence.

The SCAN Foundation was created as an independent charitable organization in April 2008 through a $205 Million one-time contribution from the not-for-profit SCAN Health Plan, a not-for-profit, Medicare Advantage based in Long Beach, California.

Previously, Dr. Mohanty served as the Vice President of Care Coordination for Medicaid and Vulnerable Populations at Kaiser Permanente; Assistant Professor of Medicine at USC; Chief Medical Officer of COPE Health Solutions, a health care management consulting company; and Senior Medical Director at L.A. Care, the largest U.S. public health plan.

Dr. Mohanty completed her Internal Medicine residency at Beth Israel Deaconess Medical Center and research fellowship at Harvard Medical School. She earned her MD from Boston University, MPH from Harvard University, and MBA from UCLA. She completed undergraduate work at UC Berkeley. She currently is an Associate Professor at the Kaiser Permanente Bernard J. Tyson School of Medicine and is a practicing internal medicine physician with Kaiser Permanente.

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These days when we are struggling with the pandemic, even breathing with peace of mind has become challenging. Especially the form of the mammalian respiratory system, requiring inhalation and exhalation, leaves us more vulnerable to the propagation of viral diseases.

But now, a group of South Korean artists, Bongkyu Song of BKID and Moon&Jeon, has devised a metal lung concept that uses algae to convert carbon dioxide into oxygen. This device named Super Lung is inspired by the respiratory system of birds. Moreover, its designers assert that this concept increases mammalian respiratory efficiency by 300%. But how?

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