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Category: biotech/medical – Page 1,161

Immune checkpoint inhibitors: Immunotherapy for people with triple-negative breast cancer

Immunotherapy is a type of drug that might be an option if you have triple-negative breast cancer.

Triple-negative breast cancer, also called basal-like breast cancer, is not sensitive to hormones. This means that the breast cancer cells don’t use estrogen or progesterone to grow and they don’t have hormone receptors. This type of breast cancer also doesn’t produce too much of the growth-promoting protein called HER2.

“Triple-negative breast cancer is about 10% to 15% of all breast cancer cases,” says Pooja Advani, M.D., a medical oncologist with the Robert and Monica Jacoby Center for Breast Health at Mayo Clinic in Florida.

USDA approves GMO purple tomato with brain-boosting and cancer-fighting properties

Although genetically modified foods still get a bit of a bad rap, there are actually many good reasons why modifying an organism’s genetics may be worthwhile. For example, many breeds of genetically modified foods have made them more resistant to disease.

It’s also possible to modify foods to make them more nutritious. Take, for example, golden rice. This grain was engineered to have higher levels of vitamin A in order to tackle deficiencies of this nutrient in impoverished countries.

A purple tomato, created using genetic modification, may be available to buy in the U.S. as soon as 2023.

New Biomarker Test Can Detect Alzheimer’s Neurodegeneration in Blood

PITTSBURGH — A group of neuroscientists led by a University of Pittsburgh School of Medicine researcher developed a test to detect a novel marker of Alzheimer’s disease neurodegeneration in a blood sample. A study on their results was published today in Brain.

The biomarker, called “brain-derived tau,” or BD-tau, outperforms current blood diagnostic tests used to detect Alzheimer’s-related neurodegeneration clinically. It is specific to Alzheimer’s disease and correlates well with Alzheimer’s neurodegeneration biomarkers in the cerebrospinal fluid (CSF).

A group of neuroscientists led by a Pitt School of Medicine researcher developed a test to detect a novel marker of Alzheimer’s disease neurodegeneration in a blood sample.

Sepsis is one of the most expensive medical conditions in the world: Research clarifies how it can lead to cell death

Sepsis is a life-threatening condition arising from the body’s overreactive response against an infection, leading it to injure its own tissues and organs. The first known reference to “sepsis” dates back more than 2,700 years, when the Greek poet Homer used it as a derivative of the word “sepo,” meaning “I rot.”

Despite dramatic improvements in understanding the immunological mechanisms behind , it still remains a major medical concern, affecting 750,000 people in the U.S. and nearly 50 million people globally each year. Sepsis accounted for 11 million deaths worldwide in 2017, and is the most expensive medical condition in the U.S., costing over tens of billions of dollars annually.

We are researchers who study how certain types of bacteria interact with cells during infections. We wanted to understand exactly how an overreactive can result in detrimental and even lethal effects like sepsis. In our research, newly published in Science Immunology, we discovered the cells and molecules that potentially trigger death from sepsis.

Please share

I missed his interview six times over the past year. Dr. Ian Hale of London who has done research a epidemics of the past 2,500 years agreed to give his interview for the seventh time and this time it happened.
The summary which I outlined from our discussion is
1-Any epidemic has a minimum four years cycle and its true about CORONA too.
2–2023 will be a catastrophic year due to the spread of mutants first in Northern Hemisphere and then in the Southern.
3-The world needs to act together to save generations whether it’s creating hospitals, vaccines, masks, or creating awareness.
4-CORONA will stay for all time. For the first few years catastrophically and then in its mild form.
5-We need to get vaccinated, wear masks, avoid public gatherings and follow all precautions.
6-Situation will be worsening in 2023 across the world due to the spread of mutants.
7-Vaccines may not work on These mutants.

Experts Debate the Risks of Made-to-Order DNA

In November 2016, virologist David Evans traveled to Geneva for a meeting of a World Health Organization committee on smallpox research. The deadly virus had been declared eradicated 36 years earlier; the only known live samples of smallpox were in the custody of the United States and Russian governments.

Evans, though, had a striking announcement: Months before the meeting, he and a colleague had created a close relative of smallpox virus, effectively from scratch, at their laboratory in Canada. In a subsequent report, the WHO wrote that the team’s method “did not require exceptional biochemical knowledge or skills, significant funds, or significant time.”

Evans disagrees with that characterization: The process “takes a tremendous amount of technical skill,” he told Undark. But certain technologies did make the experiment easier. In particular, Evans and his colleague were able to simply order long stretches of the virus’s DNA in the mail, from GeneArt, a subsidiary of Thermo Fisher Scientific.

Interviews of 2022: the longevity visionaries

Five of our favourite interviews with thought leaders and investors on the opportunity presented by longevity.

From spending billions on research to calls for fundamental changes to way we deliver healthcare, this year we heard from a host of thought leaders who shared their views on how to make longevity a reality. Today we bring you five of the best.

When we spoke to Professor Sir John Bell, we expected to learn more about a new UK initiative to study of the health of five million citizens to enable more effective ways to prevent, detect and treat diseases. But what we got was a stirring call to action for a change in the way healthcare is conducted.