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Dogma-defying biology

Many of the proteins that play a crucial role in living cells adhere to a core principle of biology: their form, or shape, fits their function. But there is also a vast number of proteins and their parts that defy that dogma.

Why it matters: New findings are revealing how these flexible, disordered proteins work — and deciphering their role in human diseases and potential treatments.

How it works: Whether many medicines, immune cells, or the moment-to-moment inner workings of cells function depends on the shape of proteins they interact with or use.

10 Upcoming Future Technologies: How They’ll Impact Your Life

Top 10 upcoming future technologies | trending technologies | 10 upcoming tech.

Future technologies are currently developing at an acclerated rate. Future technology ideas are being converted into real life at a very fast pace.

These Innovative techs will address global challenges and at the same time will make life simple on this planet. Let’s get started and have a look at the top technologies of the future | Emerging technologies.

#futuretechnologies #futuretech #futuristictechnologys #emergingtechnologies #technology #tech #besttechnology #besttech #newtechnology #cybersecurity #blockchain #emergingtech #futuretechnologyideas #besttechnologies #innovativetechs.

Chapters.
00:00 ✅ Intro.
00:23 ✅ 10. Genomics: Device to improve your health.
01:13 ✅ 09. New Energy Solutions for the benefit of our environment.
01:53 ✅ 08. Robotic Process Automation: Technology that automates jobs.
02:43 ✅ 07. Edge Computing to tackle limitations of cloud computing.
03:39 ✅ 06. Quantum Computing: Helping to stop the spread of diseases.
04:31 ✅ 05. Augmented reality and virtual reality: Now been employed for training.
05:05 ✅ 04. Blockchain: Delivers valuable security.
05:50 ✅ 03. Internet of things: So many things can connect to the internet and to one another.
06:40 ✅ 02. Cyber Security to improve security.
07:24 ✅ 01. 3D Printing: Used to create prototypesfuturistic technologybest future tech.

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Scientists Grew Mini Human Guts Inside Mice

The organoids can be used to study the development of diseases and the effects of drugs.

Michael Helmrath, a pediatric surgeon at Cincinnati Children’s Hospital Medical Center, and his colleagues made headlines last week when they revealed trials where they had transplanted balls of human intestinal tissue into mice, according to a report by *Wired* published on Thursday.

After a few weeks, these transplants developed key features of the human immune system, introducing a model that could be used to effectively simulate the human intestinal system.

It’s not the first time researchers at Cincinnati Children’s make such an advancement in organoids (miniature replicas of human organs). In 2010, the institution became the first in the world to create a working intestinal organoid. ## Containing human cells

Since organoids contain human cells and exhibit some of the same structures and functions as real organs, scientists everywhere are using them to study how organs develop, how diseases occur and how drugs work.

“It’s incredibly important that when we are trying to create these platforms for testing drug efficacy and drug side effects in human tissue models that we actually make sure that we are as close to, and as complete as, the tissue in which the drug will work eventually in our human body. So, adding the immune system is an important part of that,” told *Wired* Pradipta Ghosh, director of the Humanoid Center of Research Excellence at the University of California San Diego School, which is engineering human organoids to test drugs. Ghosh was not part of the new study.

Helmrath and his team started with induced pluripotent stem cells, which can turn into any type of body tissue, and fed them a specific molecular cocktail to coax them into transforming into intestinal cells. They ended up with some organoid spheres that the team then carefully transplanted into mice.

Antibiotic Breakthrough: The Power of a Plant-Derived Toxin

A powerful plant-derived toxin with a unique way of killing harmful bacteria has been identified as one of the most promising new antibiotics in decades.

Albicidin, a new antibiotic, is produced by the plant pathogen Xanthomonas albilineans, responsible for causing sugar cane’s destructive leaf scald disease. The toxin is believed to aid the pathogen’s spread by attacking the plant. Albicidin has been shown to be highly effective against harmful bacteria, including drug-resistant superbugs such as E. coli and S. aureus.

Despite its antibiotic potential and low toxicity in pre-clinical experiments, pharmaceutical development of albicidin has been hampered because scientists did not know precisely how it interacted with its target, the bacterial enzyme DNA.

Scientists Transplant Human Brain Organoids Into Adult Rats — And They Respond to Visual Stimuli

In a study published in the journal Cell Stem Cell on February 2, researchers show that brain organoids—clumps of lab-grown neurons—can integrate with rat brains and respond to visual stimulation like flashing lights.

Decades of research has shown that we can transplant individual human and rodent neurons into rodent brains, and, more recently, it has been demonstrated that human brain organoids can integrate with developing rodent brains. However, whether these organoid grafts can functionally integrate with the visual system of injured adult brains has yet to be explored.

“We focused on not just transplanting individual cells, but actually transplanting tissue,” says senior author H. Isaac Chen, a physician and Assistant Professor of Neurosurgery at the University of Pennsylvania. “Brain organoids have architecture; they have structure that resembles the brain. We were able to look at individual neurons within this structure to gain a deeper understanding of the integration of transplanted organoids.”

Developing Smarter, Faster Machine Intelligence with Light

SUMMARY Researchers at the George Washington University, together with researchers at the University of California, Los Angeles, and the deep-tech venture startup Optelligence LLC, have developed an optical convolutional neural network accelerator capable of processing large amounts of information, on the order of petabytes, per second. This innovation, which harnesses the massive parallelism of light, heralds a new era of optical signal processing for machine learning with numerous applications, including in self-driving cars, 5G networks, data-centers, biomedical diagnostics, data-security and more.

THE SITUATION Global demand for machine learning hardware is dramatically outpacing current computing power supplies. State-of-the-art electronic hardware, such as graphics processing units and tensor processing unit accelerators, help mitigate this, but are intrinsically challenged by serial data processing that requires iterative data processing and encounters delays from wiring and circuit constraints. Optical alternatives to electronic hardware could help speed up machine learning processes by simplifying the way information is processed in a non-iterative way. However, photonic-based machine learning is typically limited by the number of components that can be placed on photonic integrated circuits, limiting the interconnectivity, while free-space spatial-light-modulators are restricted to slow programming speeds.

THE SOLUTION To achieve a breakthrough in this optical machine learning system, the researchers replaced spatial light modulators with digital mirror-based technology, thus developing a system over 100 times faster. The non-iterative timing of this processor, in combination with rapid programmability and massive parallelization, enables this optical machine learning system to outperform even the top-of-the-line graphics processing units by over one order of magnitude, with room for further optimization beyond the initial prototype.

CrowdStrike exec explains why the cloud is a ‘net-positive’ for cybersecurity

Check out all the on-demand sessions from the Intelligent Security Summit here.

In recent years, cloud computing has proven itself as one of the fundamental technologies empowering modern enterprises with on-demand connectivity. Without it, the widespread move toward hybrid work wouldn’t have been possible during the COVID–19 pandemic. Yet what about cybersecurity in this new cloud-centric world?

The convenience of instant connectivity has created new vulnerabilities for security teams to confront, and many organizations are still playing catchup, with 81% of organizations experiencing cloud-related security incidents in the past year.

The spillover of bird flu to mammals must be ‘monitored closely,’ WHO officials warn: ‘We need to be ready to face outbreaks in humans’

H5N1 avian flu has existed for a quarter century. Only rarely have human cases occurred, with no sustained transmission reported. But “we cannot assume that will remain the case,” WHO Director General Tedros Adhanom Ghebreyesus said at a news conference. New, frequent reports that the disease has crossed into small mammals like minks, otters, foxes, and sea lions are cause for alarm, given the species’ similarities with humans, he noted.

While the risk to people remains low, public health officials must prepare “to face outbreaks in humans, and be ready also to control them as soon as possible,” Dr. Sylvie Briand, director of Global Infectious Hazard Preparedness and Emergency Preparedness at the WHO, told Fortune.

Ghebreyesus cautioned against touching or collecting sick or dead animals, and encouraged those who encounter such to report them to local authorities. Countries must strengthen their avian flu surveillance in areas where humans and wild animals interact, he insisted. And public health officials must work with manufacturers to ensure that vaccines and antivirals are available for global use, he said.

New Brain Atlases and Digital Tools Promise to Make Brain Research More Efficient

Summary: Advancements in brain mapping and the development of new digital tools over the past decade have opened the door to exciting new discoveries in neuroscience and brain sciences.

Source: University of Oslo.

A billion people worldwide suffer from brain diseases such as dementia, addiction and depression. Scientists carrying out brain research at UiO are now contributing to a more efficient utilization of research data by developing 3D brain atlases and new analytic tools.