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//Although lipomatosis is very common and increases with age, scientists have previously devoted little discussion and research to it. Scientists at Uppsala University have just published a study that offers significant insights into the causes of human lymph node function decline with aging and the effects on immune system performance.
Scientists carefully examined more than 200 lymph nodes to show that lipomatosis starts in the medulla, which is the center of the lymph node. They also provided evidence connecting lipomatosis to converting lymph node supporting cells (fibroblasts) into adipocytes (fat cells). They also demonstrate that fibroblast subtypes in the medulla are more likely to develop into adipocytes.\.
The study is a first step toward understanding why lipomatosis occur.
Framing the process of ageing more as a treatable condition, rather than an inevitable consequence of life, could allow people to live longer, thanks to emerging biotechnologies and a greater emphasis on healthy living.
Our work advances SOTA in 7 medical question-answering tasks, including achieving 67% on MedQA USMLE improving prior work by >17%. https://arxiv.org/abs/2212.
Once deemed dangerous and illegal, psychedelic compounds have been rediscovered by the scientific, medical and psychiatric communities as research reveals their capacity to help patients with a range of maladies. With investors beginning to flood this new market with capital, will Big Pharma join in, or try to squash a nascent revolution of the mind?
#Moonshots #Psychedelics #BloombergQuicktake. ——- “Moonshot” introduces you to the scientists and thinkers chasing humanity’s wildest dreams. The series takes a deeper look into how science is solving the world’s most complex problems in order to create a better tomorrow. The first season explores major breakthroughs from scientists including plastic eating bacteria, asteroid hunting and oceanic exploration. Watch every episode: https://youtube.com/playlist?list=PLqq4LnWs3olXYh0FhU2KgOg1Mzleojbie.
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NOTE FROM TED: Please do not look to this talk for mental health advice. This talk represents the speaker’s personal views and interpretation of psychedelics and mental health, which remains an emerging field of study. We’ve flagged this talk because it falls outside the content guidelines TED gives TEDx organizers. TEDx events are independently organized by volunteers. The guidelines we give TEDx organizers are described in more detail here: http://storage.ted.com/tedx/manuals/tedx_content_guidelines.pdf.
Psychedelics as medicine to treat mental health disease has had a recent resurgence of attention and dedicated research, with encouraging results. Could this class of drugs serve as a paradigm shift in the way mindfulness therapy and mental health is approached? Compounds like LSD, DMT, psilocybin, and MDMA are investigated as treatments for states of anxiety, depression, PTSD, and addiction. Listeners are challenged to question their preconceived notions and judgements as it pertains to this group of restricted therapeutics in the psychedelic class. Burton J. Tabaac, MD FAHA
Burton is an associate professor of neurology at the University of Nevada, Reno School of Medicine, dedicated to the cutting-edge treatment and prevention of cerebrovascular diseases. He is a graduate of the fellowship program in vascular neurology at Johns Hopkins University Hospital in Baltimore, MD (2019). After graduating from AUC School of Medicine, where he earned his MD (2014), Tabaac completed a neurology residency at Rutgers Robert Wood Johnson in New Brunswick, NJ. There, he was humbled to have been selected as a three-time recipient of The Arnold P. Gold Foundation’s Humanism and Excellence in Teaching Award (2016, 2017, and 2018). This talk was given at a TEDx event using the TED conference format but independently organized by a local community.
With Augmented Humanity we will travel from the US to Japan, into the heart of secret labs of the most borderline scientists in the world, who try to push the boundaries of life through technology. Robotics is an important step, but the future of our species is not in a massive substitution by robots, on the contrary, robotics and technology must be used to improve the human being.
ENDEVR explains the world we live in through high-class documentaries, special investigations, explainers videos and animations. We cover topics related to business, economics, geopolitics, social issues and everything in between that we think are interesting.
TMCs are responsible for all aspects of data generation from tissue collection and analysis to data integration and interpretation. We anticipate that TMCs will acquire and integrate imaging and omics data to benchmark, standardize and validate SnC maps at single-cell resolution for their assigned tissues. The TDA sites are responsible for development of innovative, new approaches and tools necessary to deeply phenotype SnCs in human tissues and model systems. Examples include multi-omics characterization of the 4D nucleome in SnCs, high-throughput quantification of telomere-associated foci, and in vivo detection of SnCs via positron emission tomography imaging. Once developed, these new technologies are expected to be applied broadly and collaboratively across multiple tissues by the TMCs. The CODCC will collect, store and curate all data and metadata generated by the TMCs and TDA sites. The CODCC is responsible for generating the computational models, and final atlas products as well as the tools to visualize and disseminate the data as a resource for the broad scientific community.
It is expected that SenNet will interface with other cell mapping programs such as Human Bimolecular Atlas Program (HuBMAP), Human Cell Atlas (HCA) and the Kidney Precision Medicine Project (KPMP). HuBMAP is an NIH Common Fund Initiative to develop the resources and framework to map the 30 trillion cells that make up the human body using protein identifiers of cell lineage. HCA is using single-cell and spatial transcriptomics to create cell reference maps defining the position, function and characteristics of all cells in the human body. The KPMP is an initiative of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) aimed at using state-of-the-art and emerging technologies to characterize renal biopsies from participants with acute kidney injury or chronic kidney disease to enable personalized approaches to their treatment.
