Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 1,010

Dr Andrew McMahon & Lewis Kleinberg — Pushing The Boundaries Of Research To Build A Synthetic Kidney

Pushing The Boundaries Of Research To Build A Synthetic Kidney — Dr. Andrew McMahon, Ph.D. & Lewis Kleinberg, University Kidney Research Organization (UKRO)

The University Kidney Research Organization (UKRO — https://ukrocharity.org/) is a Los Angeles-based nonprofit charity, co-founded prominent entertainment attorney Kenneth Kleinberg, inspired by his personal journey with kidney disease, focused on supporting medical research and education related to the causes, treatment, and eradication of all forms of kidney disease.

Dr. Andrew McMahon, Ph.D. (https://keck.usc.edu/faculty-search/andrew-p-mcmahon/) is Director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Provost Professor and the inaugural holder of the W. M. Keck Professorship of Stem Cell Biology and Regenerative Medicine, and is responsible for overseeing UKRO’s Synthetic Kidney Project. In addition, Dr. McMahon chairs the recently created Department of Stem Cell Biology and Regenerative Medicine at the Keck School. He also holds an appointment in the Department of Biological Sciences in the USC Dornsife College of Letters, Arts, and Sciences.

Previously Dr. McMahon served as professor in the Department of Stem Cell and Regenerative Biology, Department of Molecular and Cellular Biology and principal faculty member in the Harvard Stem Cell Institute, as well as led the Department of Cell and Developmental Biology at the Roche Institute for Molecular Biology.

Dr. McMahon received his bachelor’s degree from St. Peter’s College, Oxford University and his Ph.D. from University College in London. He subsequently worked for three years as a postdoctoral fellow at the California Institute of Technology.

Continue reading “Dr Andrew McMahon & Lewis Kleinberg — Pushing The Boundaries Of Research To Build A Synthetic Kidney” | >

NF-κB Decoy ODN-Loaded Poly(Lactic-co-glycolic Acid) Nanospheres Inhibit Alveolar Ridge Resorption

Residual ridge resorption combined with dimensional loss resulting from tooth extraction has a prolonged correlation with early excessive inflammation. Nuclear factor-kappa B (NF-κB) decoy oligodeoxynucleotides (ODNs) are double-stranded DNA sequences capable of downregulating the expression of downstream genes of the NF-κB pathway, which is recognized for regulating prototypical proinflammatory signals, physiological bone metabolism, pathologic bone destruction, and bone regeneration. The aim of this study was to investigate the therapeutic effect of NF-κB decoy ODNs on the extraction sockets of Wistar/ST rats when delivered by poly(lactic-co-glycolic acid) (PLGA) nanospheres.

Read more | >

What are Cognitive Light Cones? (Michael Levin Interview)

Michael Levin’s 2019 paper “The Computational Boundary of a Self” is discussed. The main topics of conversation include Scale-Free Cognition, Surprise & Stress, and the Morphogenetic Field. Michael Levin is a scientist at Tufts University; his lab studies anatomical and behavioral decision-making at multiple scales of biological, artificial, and hybrid systems. He works at the intersection of developmental biology, artificial life, bioengineering, synthetic morphology, and cognitive science.

🚩The Computational Boundary of a Self: Developmental Bioelectricity Drives Multicellularity and Scale-Free Cognition (can read in browser or download as pdf)
https://www.frontiersin.org/articles/10.3389/fpsyg.2019.02688/full.

❶ Scale-Free Cognition.
3:05 Ultimate question of the embodied mind.
5:50 The most difficult interview to prepare for.
6:55 One of my favorite papers of all time (screenshare)
7:40 The Computational Boundary of a Self.
9:25 Defining intelligence (cybernetics)
10:30 Cognitive light cones.
16:50 All intelligence is collective intelligence.
17:35 Nested selves vs. one integrated self (Not Integrated Information Theory)
21:10 The same dynamics in the brain occur in every tissue of the body.
22:50 Why scale “free” cognition?

❷ Stress & Surprise.
27:22 Stress = Surprise?
30:30 Intelligence within a salamander example (homeostatic capability of collective intelligence)
33:35 The scale-free importance of stress.
37:30 Stress is an exported error signal.
40:45 Stress means your problem becomes everyone’s problem (cooperation without altruism)
42:25 Stress has no ownership metadata (gap junctions permit mind meld)

❸ The Morphogenetic Field.
49:00 About 99% of the Shannon information in a cell is in the membrane and transmembrane gradient (Bob Gatenby)
52:25 Shannon information doesn’t distinguish meaning… 55:53 Cancer cells have the wrong scope of “self” 1:01:17 Manipulating cells via retraining vs micromanaging 1:04:45 “Drugs and words have the same mechanisms of action”-Fabrizio Benedetti 1:07:10 Morphogenetic field of signals coordinating cell behavior, bioelectricity special layer (screenshare) 1:11:13 Harold Saxton Burr predicted this 100 years ago! 1:14:50 Connections to Zen Buddhism 1:18:18 Find more of Levin’s work 🚩Links to Levin 🚩 https://youtube.com/watch?v=YnObwxJZpZc&feature=share https://twitter.com/drmichaellevin https://www.drmichaellevin.org/ https://as.tufts.edu/biology/levin-lab Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds (2022) https://www.frontiersin.org/articles/.… Buddhism, and AI: Care as the Driver of Intelligence (2022) https://www.mdpi.com/1099-4300/24/5/710 Emergence of informative higher scales in biological systems: a computational toolkit for optimal prediction and control (2020) https://www.tandfonline.com/doi/full/.… 🚾 Works Cited Jeremy Quay (visual artist) at https://peregrinecr.com/ https://en.wikipedia.org/wiki/William… https://en.wikipedia.org/wiki/Harold_… There’s Plenty of Room Right Here: Biological Systems as Evolved, Overloaded, Multi-Scale Machines (Bongard & Levin 2023) https://www.mdpi.com/2313-7673/8/1/110 Bob Gatenby talk on “Information Dynamics in Living Systems” • Bob Gatenby talk…

🚨 Note.

Continue reading “What are Cognitive Light Cones? (Michael Levin Interview)” | >

MIT scientists discover ‘remarkable’ way to reverse Alzheimer’s disease

Scientists at MIT have unlocked a major breakthrough in the battle to reverse the effects of Alzheimer’s disease — one that shows “dramatic reductions” in neurodegeneration, a report stated. The exciting achievement came about after researchers were able to interfere with an enzyme typically found to be overactive in the brains of Alzheimer’s patients.

Read more | >

Novel device smaller than rice successfully shrinks pancreatic cancer

Called the nanofluidic drug-eluting seed (NDES), it delivers low-dose immunotherapy in the form of CD40 monoclonal antibodies (mAb).

In a significant groundbreaking medical development, researchers have created a tiny device, smaller than a grain of rice, to deliver drugs directly to the pancreatic tumor.

Nano-device uses less dosage to shrink cancer.

Houston Methodist.

In the near future, this implantable nanofluidic device could be a game changer in treating pancreatic cancer. Nanomedicine experts at Houston Methodist Academic Institute developed the device.

Read more | >

Scientists Merge Biology and Technology

Finding ways to integrate electronics into living tissue could be crucial for everything from brain implants to new medical technologies. A new approach has shown that it’s possible to 3D print circuits into living worms.

There has been growing interest in finding ways to more closely integrate technology with the human body, in particular when it comes to interfacing electronics with the nervous system. This will be crucial for future brain-machine interfaces and could also be used to treat a host of neurological conditions.

But for the most part, it’s proven difficult to make these kinds of connections in ways that are non-invasive, long-lasting, and effective. The rigid nature of standard electronics means they don’t mix well with the squishy world of biology, and getting them inside the body in the first place can require risky surgical procedures.

Read more | >

CRISPR Breakthrough: Scientists Can Now Turn Genes On and Off at Whim

The gene-editing system CRISPR-Cas9 which has revolutionized genetic engineering over the past decade involves cutting DNA strands which is a process that can be quite hard to control and can result in unwanted genetic changes. Now, thanks to researchers at the Massachusetts Institute of Technology and the University of California, San Francisco (UCSF), a new gene-editing technology called CRISPRoff can change that, according to a press release.

“Fast forward four years [from the initial grant], and CRISPRoff finally works as envisioned in a science fiction way,” says co-senior author Luke Gilbert. “It’s exciting to see it work so well in practice.”

Read more | >

QuASeR: Quantum Accelerated de novo DNA sequence reconstruction

In this, we present QuASeR, a reference-free DNA sequence reconstruction implementation via de novo assembly on both gate-based and quantum annealing platforms. This is the first time this important application in bioinformatics is modeled using quantum computation. Each one of the four steps of the implementation (TSP, QUBO, Hamiltonians and QAOA) is explained with a proof-of-concept example to target both the genomics research community and quantum application developers in a self-contained manner. The implementation and results on executing the algorithm from a set of DNA reads to a reconstructed sequence, on a gate-based quantum simulator, the D-Wave quantum annealing simulator and hardware are detailed. We also highlight the limitations of current classical simulation and available quantum hardware systems. The implementation is open-source and can be found on https://github.com/QE-Lab/QuASeR.

Citation: Sarkar A, Al-Ars Z, Bertels K (2021) QuASeR: Quantum Accelerated de novo DNA sequence reconstruction. PLoS ONE 16: e0249850. https://doi.org/10.1371/journal.pone.

Editor: Archana Kamal, University of Massachusetts Lowell, UNITED STATES.

Read more | >

Study unveils neural processes underpinning the re-emergence of consciousness after anesthesia

Before undergoing surgeries and other invasive medical procedures, patients typically undergo anesthesia. Anesthesia consists in giving patients a class of drugs (i.e., anesthetics) that cause them to lose feeling in specific areas of the body (i.e., local anesthesia) or fully lose awareness during a procedure (i.e., general anesthesia). These anesthetics can be administered to patients via injection, inhalation, skin-numbing lotions, and other means.

In the past, doctors and viewed as a passive process that could not be influenced or interrupted once drugs were administered. More recently, however, studies showed that it is in fact an active process that can be experimentally controlled and acted on.

A research team at the Southern University of Science and Technology in China recently carried out a study investigating the processes underpinning while under general and those associated with the subsequent re-emergence of awareness. Their findings, published in Nature Neuroscience, highlight possible strategies that could help anesthesiologists to extend and deepen or shorten periods of anesthesia.

Read more | >