Lifeboat Foundation

They are part of the brain of almost every animal species, yet they remain usually invisible even under the electron microscope. “Electrical synapses are like the dark matter of the brain,” says Alexander Borst, director at the MPI for Biological Intelligence, in foundation (i.f). Now a team from his department has taken a closer look at this rarely explored brain component: In the brain of the fruit fly Drosophila, they were able to show that electrical synapses occur in almost all brain areas and can influence the function and stability of individual nerve cells.

Neurons communicate via synapses, small contact points at which chemical messengers transmit a stimulus from one cell to the next. We may remember this from biology class. However, that is not the whole story. In addition to the commonly known chemical synapses, there is a second, little-known type of synapse: the electrical synapse. “Electrical synapses are much rarer and are hard to detect with current methods. That’s why they have hardly been researched so far,” explains Georg Ammer, who has long been fascinated by these hidden cell connections. “In most animal brains, we therefore don’t know even basic things, such as where exactly electrical synapses occur or how they influence brain activity.”

An electrical synapse connects two neurons directly, allowing the electrical current that neurons use to communicate, to flow from one cell to the next without a detour. Except in echinoderms, this particular type of synapse occurs in the brain of every animal species studied so far. “Electrical synapses must therefore have important functions: we just do not know which ones!” says Georg Ammer.

NASA’s Artemis mission has the chief goals of sending astronauts to establish the first long-term presence on the Moon and learning what is necessary to send the first astronauts to Mars. But it’s also planning to do so much more than that.

One of its many scientific mission will see the agency send the Lunar Vulkan Imaging and Spectroscopy Explorer (Lunar-VISE) and the Lunar Explorer Instrument for space biology Applications (LEIA) to the Moon in order to explore the mysterious Gruithuisen Domes, geological features that have puzzled scientists for years.

Plastic bottles, punnets, wrap – such lightweight packaging made of PET plastic becomes a problem if it is not recycled. Scientists at Leipzig University have now discovered a highly efficient enzyme that degrades PET in record time. The enzyme PHL7, which the researchers found in a compost heap in Leipzig, could make biological PET recycling possible much faster than previously thought. The findings have now been published in the scientific journal “ChemSusChem” and selected as the cover topic.

One way in which enzymes are used in nature is by bacteria to decompose plant parts. It has been known for some time that some enzymes, so-called polyester-cleaving hydrolases, can also degrade PET. For example, the enzyme LCC, which was discovered in Japan in 2012, is considered to be a particularly effective “plastic eater”. The team led by Dr Christian Sonnendecker, an early career researcher from Leipzig University, is searching for previously undiscovered examples of these biological helpers as part of the EU-funded projects MIPLACE and ENZYCLE. They found what they were looking for in the Südfriedhof, a cemetery in Leipzig: in a sample from a compost heap, the researchers came across the blueprint of an enzyme that decomposed PET at record speed in the laboratory.

The researchers from the Institute of Analytical Chemistry found and studied seven different enzymes. The seventh candidate, called PHL7, achieved results in the lab that were significantly above average. In the experiments, the researchers added PET to containers with an aqueous solution containing either PHL7 or LCC, the previous leader in PET decomposition. Then they measured the amount of plastic that was degraded in a given period of time and compared the values with each other.

Spike-based neuromorphic hardware holds the promise to provide more energy efficient implementations of Deep Neural Networks (DNNs) than standard hardware such as GPUs. But this requires to understand how DNNs can be emulated in an event-based sparse firing regime, since otherwise the energy-advantage gets lost. In particular, DNNs that solve sequence processing tasks typically employ Long Short-Term Memory (LSTM) units that are hard to emulate with few spikes. We show that a facet of many biological neurons, slow after-hyperpolarizing (AHP) currents after each spike, provides an efficient solution. AHP-currents can easily be implemented in neuromorphic hardware that supports multi-compartment neuron models, such as Intel’s Loihi chip. Filter approximation theory explains why AHP-neurons can emulate the function of LSTM units.

https://www.youtube.com/watch?v=n9IxomBusuw.

Key points of the 2hrs+ long interview between dr. Andrew Huberman and dr. David Sinclair.

Continue reading “Summary of: The Biology of Slowing and Reversing Aging | Andrew Huberman & David Sinclair” »

Amazon and Max Planck Society announced the formation of a Science Hub—a collaboration that marks the first Amazon Science Hub to exist outside the United State… See more.

Amazon and Max Planck Society (also known as Max-Planck-Gesellschaft or MPG) today announced the formation of a Science Hub. The collaboration marks the first Amazon Science Hub to exist outside the United States and will focus on advancing artificial intelligence research and development throughout Germany.

The hub’s goal is to advance the frontiers of AI, computer vision, and machine learning research to ensure that research is creating solutions whose benefits are shared broadly across all sectors of society. To achieve that end, the collaboration will include sponsored research; open research; industrial fellowships co-supervised by Max Planck and Amazon; and community events funding to enrich the MPG and Amazon research communities.

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Incredible and somewhat frightening visions of the future will become a reality in the coming decades. According to futurologists, people of the future will gain immortality and will live in the body of a machine. Dr. Ian Pearson predicts that a person will be able to transfer his mind into a computer and one day he will go to a funeral where his previous biological body will be buried. Like anomalien.com on Facebook To stay in touch & get our latest news Cyborgization has some good sides. Let us take into account that we will be able to exchange each of…

Can quantum science supercharge genetics? | Jim Al-Khalili for Big Think.

This interview is an episode from The Well, our new publication about ideas that inspire a life well-lived, created with the John Templeton Foundation.

Continue reading “What if quantum physics could eradicate illness? | Jim Al-Khalili for Big Think” »

For the first time TU Graz’s Institute of Theoretical Computer Science and Intel Labs demonstrated experimentally that a large neural network can process sequences such as sentences while consuming four to sixteen times less energy while running on neuromorphic hardware than non-neuromorphic hardware. The new research based on Intel Labs’ Loihi neuromorphic research chip that draws on insights from neuroscience to create chips that function similar to those in the biological brain.

The research was funded by The Human Brain Project (HBP), one of the largest research projects in the world with more than 500 scientists and engineers across Europe studying the human brain. The results of the research are published in Nature Machine Intelligence (“Memory for AI Applications in Spike-based Neuromorphic Hardware”).

The close-up shows an Intel Nahuku board, each of which contains eight to 32 Intel Loihi neuromorphic research chips. (Image: Tim Herman, Intel Corporation)