Lifeboat Foundation

3D printed ovaries restore fertility to mice. Another step towards more complex organs.

There is a clinical need to develop a bioengineering system to support ovary transplantation. Here, the authors generate a bioprosthetic ovary using 3D printed scaffolds of varying pore architectures to support follicle survival and ovarian function in sterilized mice.

CellAge, the synthetic biology company are going from strength to strength thanks to the support of the community last year during their fundraiser at Lifespan.io.

CellAge is featured in Startup Lithuania. As many of you will recall, CellAge hosted a successful project with us at Lifespan.io and they are busy developing a new aging biomarker for researchers thanks to the support of the community.

Now they are going from strength to strength having just secured a seed round backed by Michael Greve’s Kizoo Technology Capital and other investors.

Continue reading “CellAge Has Secured a Seed Fundraising Round” »

Scientists’ ability to create organisms through synthetic biology is getting easier and cheaper fueling the start of a new era in biology. Synthetic biology has already lead to some innovations such as lab-grown meat, advancement in medicine, and even helping to bring back extinct species.

To Dr. Mark Gomelsky, a professor at the University of Wyoming, genetically engineered therapeutic cells are like troops on a mission.

The first act is training. Using genetic editing tools such as CRISPR, scientists can “train” a patient’s own cells to specifically recognize and attack a variety of enemies, including rogue tumor soldiers and HIV terrorists.

Then comes the incursion. Engineered cells are surgically implanted to the target site, where they’re left to immediately carry out the mission. The problem, says Gomelsky, is adding a command center “that could coordinate their activities in real time according to the developing situation,” such as telling cells when to activate and when to stop.

Continue reading “These Cells Are Engineered to Be Controlled by a Smartphone” »

A new story out on #transhumanism:

In the Basic Income America Facebook group, Zoltan Istvan, a transhumanist who recently ran for president, shared his Wired article, Capitalism 2.0: the economy of the future will be powered by neural lace. He (along with many others) argues Wall Street, law offices, engineering firms, and more will soon be mostly void of humans.

I think I mostly agree with him. Algorithms will far surpass human ability to achieve the best possible outcomes (Nash equilibrium). Having read Super Intelligence, the Master Algorithm, The Age of Em, books on evolution, lectures, interviews, etc… I think we’re approaching an important moment in human history where we have to figure out morality so we can build it into the proto-AI children we are giving birth to. I’ve even toyed around with a fun idea related to the simulation hypothesis. Maybe we exist as a simulation, repeating the birth of AI over and over again until we figure out a way to do it without destroying ourselves or turning the universe into computonium.

Continue reading “Are You Drinking the Transhumanist Kool-Aid?” »

One of the greatest ethical debates in science — manipulating the fundamental building blocks of life — is set to heat up once more.

According to scientists behind an ambitious and controversial plan to write the human genome from the ground up, synthesising DNA and incorporating it into mammalian and even human cells could be as little as four to five years away.

Nearly 200 leading researchers in genetics and bioengineering are expected to attend a meeting in New York City next week, to discuss the next stages of what is now called the Genome Project-write (GP-write) plan: a US$100 million venture to research, engineer, and test living systems of model organisms, including the human genome.

Continue reading “Tensions Flare as Scientists Go Public With Plan to Build Synthetic Human DNA” »

The CellAge project hosted last year with Lifespan.io has now joined up with Michael Greve and Kizoo to develop this technology. Community support for the project has helped move the project foward and will hopefully speed up progress as a result.

April 2017, Edinburgh. CellAge Limited (“CellAge”) has raised a seed round backed by Michael Greve´s Kizoo Technology Capital and a group of angel investors.

CellAge, a privately held synthetic biology start-up aiming to develop tools and therapies for age-related diseases, has successfully completed a seed fundraising round. In this round Kizoo Technology Capital and a number of angel investors have joined the effort to develop synthetic promoters which will make senescent cells identification and removal safer and more efficient. To achieve this, CellAge is planning to analyze transcriptional profiles of a wide range of senescent cell types using proprietary algorithm and construct novel promoters from candidate regulatory elements identified in this screen. The joint expertise in senescence, synthetic biology and bioinformatics gives CellAge a unique angle on improving ways how gene therapies could be targeted to senescent cells.

A nice new write-up on my governor run: https://humanityplus.wordpress.com/2017/04/24/this-transhuma…alifornia/ #transhumanism

It’s a good time to be a transhumanist politician. As faith in the political establishment declines, new technologies, from gene editing to artificial intelligence, are transforming our lives faster than ever. The transhumanist author and politician Zoltan Istvan agrees. He thinks the time is ripe for pro-science and technology governance, and for leaders who will embrace the technologies that could fundamentally transform our conceptions of what it means to be human.

Istvan is a maverick who appears to thrive in an ‘outsider’ role. He self-published a sci-fi novel, The Transhumanist Wager, in 2013, which became a surprise bestseller on Amazon. In 2016, he made an unlikely run for US president as the leader of the Transhumanist Party. Now, he’s making a bid for Governor of California in the 2018 election under a Libertarian Party ticket.

Continue reading “This Transhumanist Politician Wants to be Governor of California” »

The most important set of genetic instructions we all get comes from our DNA, passed down through generations. But the environment we live in can make genetic changes, too.

Researchers have now discovered that these kinds of environmental genetic changes can be passed down for a whopping 14 generations in an animal – the largest span ever observed in a creature, in this case being a dynasty of C. elegans nematodes (roundworms).

To study how long the environment can leave a mark on genetic expression, a team led by scientists from the European Molecular Biology Organisation (EMBO) in Spain took genetically engineered nematode worms that carry a transgene for a fluorescent protein. When activated, this gene made the worms glow under ultraviolet light.

Continue reading “Scientists Have Observed Epigenetic Memories Being Passed Down for 14 Generations” »