Lifeboat Foundation: Safeguarding Humanity
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Category: bioengineering – Page 170

Recently, roughly 200 eminent scientists assembled in Boston. Their agenda? Creating “superhero” human cells impervious to all viral attacks and possibly other killers—radiation, freezing, aging, or even cancer.

The trick isn’t super-soldier serum. Instead, the team is relying on tools from synthetic biology to read the cell’s genetic blueprint and rewrite large chunks of the genome to unlock these superpowers.

“There is very strong reason to believe that we can produce cells that would be completely resistant to all known viruses,” said Dr. Jef Boeke, a geneticist at New York University and a co-leader of the project. “It should also be possible to engineer other traits, including resistance to prions and cancer.”

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In “Engineering a Traiter,” the year is 2027, and a former military officer named Jay Roberts has just engineered a missile attack in downtown Houston — except he doesn’t know that it’s his fault.

This sombre graphic novel tells the story of Roberts, an army engineer working in Texas who’s been targeted by a militia eager to gain access to building codes in order to orchestrate a terrorist attack. With sophisticated A.I., the militia manipulate everything in Roberts’s life. The news he sees is curated to instil hopelessness and despair, and family members’ social media accounts are hijacked to distance Roberts from loved ones. Frustrated and alone, he eventually confesses security information to a “friend” he’s made online, allowing the militias the access they’ve been hoping for. Once they have what they want, Roberts’ social media is manipulated to make him look like a radicalized terrorist. When the attack occurs, he takes the fall.

The narrative may be science fiction, but it paints a realistic — if not paranoid — vision of the future. That bleakness is exactly what Brian David Johnson wanted when he began penning a series of graphic novels for the Army Cyber Institute at West Point.

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https://www.wired.com/…/biology-will-be-the-next-great-comp…

In some ways, Synthego looks like any other Silicon Valley startup. Inside its beige business park facilities, a five-minute drive from Facebook HQ, rows of nondescript black server racks whir and blink and vent. But inside the metal shelving, the company isn’t pushing around ones and zeros to keep the internet running. It’s making molecules to rewrite the code of life.

Crispr, the powerful gene-editing tool, is revolutionizing the speed and scope with which scientists can modify the DNA of organisms, including human cells. So many people want to use it—from academic researchers to agtech companies to biopharma firms—that new companies are popping up to staunch the demand. Companies like Synthego, which is using a combination of software engineering and hardware automation to become the Amazon of genome engineering. And Inscripta, which wants to be the Apple. And Twist Bioscience, which could be the Intel.

All these analogies to the computing industry are more than just wordplay. Crispr is making biology more programmable than ever before. And the biotech execs staking their claims in Crispr’s backend systems have read their Silicon Valley history. They’re betting biology will be the next great computing platform, DNA will be the code that runs it, and Crispr will be the programming language.

Continue reading “Biology Will Be the Next Great Computing Platform” | >

Experts have equipped biotech workhorse bacteria with feedback control mechanism to balance growth with making protein products.

Medicines like insulin and interferon are manufactured using genetically engineered bacteria, such as E. coli. E. coli grow quickly and can be given DNA that instructs them to make proteins used in medicines and other materials.

However, the extra burden of producing new proteins hampers bacterial growth, which slows production. Solving this problem is an area of great interest for biotechnology and synthetic biology.

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