Lifeboat Foundation

Scientists have expanded the building blocks of DNA to create a stable semi-synthetic organism that can produce biological compounds entirely new to nature.

The DNA that makes up essentially all living things on Earth consists of arrangements of four basic nucleotides, but the new life-form developed by researchers in the US makes use of six – and that’s where things get interesting.

The semi-synthetic organism (SSO) engineered by a team at the Scripps Research Institute in California is made from the same four regular nucleobases as you and I – adenine (A), cytosine ©, guanine (G), and thymine (T) – but it’s also got two unnatural nucleotides to call upon.

Continue reading “New Semi-Synthetic Organism Can Make Molecules We’ve Never Seen Before” »

The sense of touch is often taken for granted. For someone without a limb or hand, losing that sense of touch can be devastating. While highly sophisticated prostheses with complex moving fingers and joints are available to mimic almost every hand motion, they remain frustratingly difficult and unnatural for the user. This is largely because they lack the tactile experience that guides every movement. This void in sensation results in limited use or abandonment of these very expensive artificial devices. So why not make a prosthesis that can actually “feel” its environment?

That is exactly what an interdisciplinary team of scientists from Florida Atlantic University and the University of Utah School of Medicine aims to do. They are developing a first-of-its-kind bioengineered robotic hand that will grow and adapt to its environment. This “living” robot will have its own peripheral nervous system directly linking robotic sensors and actuators. FAU’s College of Engineering and Computer Science is leading the multidisciplinary team that has received a four-year, $1.3 million grant from the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health for a project titled “Virtual Neuroprosthesis: Restoring Autonomy to People Suffering from Neurotrauma.”

For the first time ever, scientists have attempted to cure a person’s disease by editing a gene inside the body.

Scientists used an IV to inject a patient with billions of copies of a corrective gene and a genetic tool to cut his DNA in a specific spot. “We cut your DNA, open it up, insert a gene, stitch it back up.”

Scientists have edited people’s genes in the past, but that work involved altering cells inside a lab and then returning them to the body, whereas the latest experiment was performed inside a person’s body.

Continue reading “AP Exclusive: US scientists try 1st gene editing in the body” »

He is the first patient to receive an experimental gene therapy as part of a clinical trial. Earlier this week, Sangamo Therapeutics injected Madeux with viruses containing a package of gene-editing material, according to the AP. The hope is that these viruses will enter Madeux’s cells, specifically liver cells, inject the missing gene at the right place in his DNA. Only about 1% of the liver’s cells need to be fixed, and give his liver the ability to produce the enzyme he has been missing all his life.

Brian Madeux’s life hasn’t been easy. So far, he’s had 26 operations to fix problems in everything from hernias to eyes. He has a rare disease called Hunter syndrome, which is caused by the lack of a gene that’s used to produce an enzyme that breaks down certain carbohydrates. As a result, the carbohydrates build up in his body’s cells causing all sorts of problems.

Continue reading “Doctors are gene editing inside the body of a living human for the first time” »

The CRISPR-Cas9 system has revolutionised gene-editing, but cutting DNA isn’t all it can do. From turning gene expression on and off to fluorescently tagging particular sequences, this animation explores some of the exciting possibilities of CRISPR.

Download a poster on ‘The expanding CRISPR toolbox’ here: https://www.nature.com/posters/crisprtoolbox

Continue reading “Gene editing and beyond” »

Understanding the factors that control aging has been one of humanity’s endless pursuits, from the mystical fountain of youth to practical healthful regimens to prolong life expectancy.

A team of scientists at the University of California San Diego has helped decipher the dynamics that control how our cells age, and with it implications for extending human longevity. As described in a study published in the Proceedings of the National Academy of Sciences, a group led by biologist Nan Hao employed a combination of technologies in engineering, computer science and biology to analyze molecular processes that influence aging.

As cells age, damage in their DNA accumulates over time, leading to decay in normal functioning and eventually resulting in death. A natural biochemical process known as “chromatin silencing” helps protect DNA from damage. The silencing process converts specific regions of DNA from a loose, open state into a closed one, thus shielding DNA regions. Among the molecules that promote silencing is a family of proteins—broadly conserved from bacteria to humans—known as sirtuins. In recent years, chemical activators of sirtuins have received much attention and are being marketed as nutraceuticals to aid chromatin silencing in the hopes of slowing the aging process.

Continue reading “Scientists decipher mechanisms underlying the biology of aging” »

Over just a few short years the CRISPR gene-editing technique has revolutionized science, affecting everything from medicine to agriculture. Two new breakthrough studies have just been published describing dual methods that make the process more precise and efficient paving the way for scientists to safely alter DNA mutations that cause thousands of different human diseases.

CRISPR is conventionally a cut-and-paste tool allowing scientists to chop out unwanted strands of DNA and insert new genes, but a large volume of human diseases are caused by a single point mutation somewhere in a person’s DNA. Up until now scientists have not been able to simply and directly erase or rewrite these single mutations in living human cells.

Our human genome consists of 3 billion base pairs made up of chemical units referred to by the letters A, C, G and There are 50,000 known genetic mutations that are linked to disease in humans and 32,000 of these are single point mutations. Half of those single point mutations have been identified as a G-C pair that has mutated into an A-T pair.

While NASA and SpaceX figure out how to get to Mars, they’re also thinking about how the 200-day journey and life on the red planet will affect humans. Astronauts will be dealing with nasty things like muscle atrophy and bone loss, intra-cranial pressure, psychological issues, lack of resources and long-term radiation exposure. NASA and its partners are working on things like “torpor,” a type of space hibernation, and protective Mars cave dwellings with a view. To learn more, Engadget spoke with NASA scientist Laura Kerber and Spaceworks COO John Bradford at the Hello Tomorrow symposium in Paris.

“There are a lot of challenges that are preventing us from even getting there in a healthy state,” said Bradford in a keynote speech at the event. As a human-space-exploration expert, he’s been working on a way to mitigate many of those problems by putting astronauts in a “torpor state” of prolonged hypothermia. It not only reduces the human problems but helps with technical and engineering challenges, too.

On the medical side, it addresses the so-called psycho-social challenges (you can’t get depressed if you’re asleep), reduces intra-cranial pressure, opens up new approaches like electrostimulation to reduce muscle atrophy and bone loss, and even helps minimize radiation exposure.

Continue reading “Getting to and living on Mars will be hell on your body” »

Just like how letters are strung together to form words, our DNA is also strung together by letters to encode proteins. The genetic alphabet contains only 4 natural letters — A, C, G and T, which hold the blueprint for the production of proteins that make our bodies work. Now, researchers from the Institute of Bioengineering and Nanotechnology (IBN) of the Agency for Science, Technology and Research (A*STAR) have created a DNA technology with two new genetic letters that could better detect infectious diseases, such as dengue and Zika.

Genetic alphabet expansion technology is the introduction of artificial base pairs into DNA. The existing four genetic letters are naturally bound together in base pairs of A-T and G-C. These specific base pair formations are essential in DNA replication, which occurs in all living organisms. It is the process by which a DNA molecule is duplicated to produce two identical molecules.

“The expansion of the genetic alphabet is a significant scientific achievement. It sheds insights into DNA’s natural replication mechanism, which will help us to design unique DNA molecules and technologies. For example, our technology can be used to create novel diagnostics and therapeutic agents with superior efficacy,” said IBN Executive Director Professor Jackie Ying.