Circa 2014
An engineered bacterium is able to copy DNA that contains unnatural genetic letters.
Category: bioengineering – Page 140
Sirtuins can be activated by a lack of amino acids or of sugar, or through an increase in NAD. — David Sinclair If you have not heard of #davidsinclair then it is time you have. he is at the forefront of anti aging research and one of my heroes. While we wait for the miracle pills there are alot of thing we can do to help us age better already. #biohacking #biohacker
Can a single molecule extend lifespan?
Could be used in a portable device to genetically reprogram ones body.
Environmental conditions, such as heat, acidity, and mechanical forces, can affect the behavior of cells. Some biologists have even shown that magnetic fields can influence them. Now, for the first time, an international team reports that low-strength magnetic fields may foster the reprogramming of cellular development, aiding in the transformation of adult cells into pluripotent stem cells (ACS Nano 2014, DOI: 10.1021/nn502923s). If confirmed, the phenomenon could lead to new tools for bioengineers to control cell fates and help researchers understand the potential health effects of changing magnetic fields on astronauts.
Biologists have been building up evidence that magnetic fields affect living things, says Michael Levin, director of Tufts University’s Center for Regenerative & Developmental Biology, who was not involved in the new study. For example, plants and amphibian embryos develop abnormally when shielded from Earth’s geomagnetic field. And there’s some clinical evidence that particular electromagnetic frequencies promote bone fracture healing and wound repair (Eur. Cytokine Network 2013, DOI: 10.1684/ecn.2013.0332).
“It’s been a huge unknown how a cell senses electromagnetic fields and then translates that into a change in identity or a change in gene expression,” says Christopher J. Lengner, a cell biologist at the University of Pennsylvania. He worked with a group of bioengineers led by Jongpil Kim of Dongguk University, in Seoul, South Korea, to see if these fields could influence a process they were all interested in: reprogramming a cell’s developmental state.
Nature asked researchers and other stakeholders what hurdles remain before heritable gene editing could become acceptable as a clinical tool. Although some scientific challenges are probably surmountable, approval on a grand scale is likely to require changes to how clinical trials are run, as well as a broader consensus about the technology.
Efforts to make heritable changes to the human genome are fraught with uncertainty. Here’s what it would take to make the technique safe and acceptable.
Ever wonder why some fortunate people eat chips, don’t exercise, and still don’t get clogged arteries? It could be because they’ve got lucky genes.
Now Alphabet (Google’s parent company) is bankrolling a startup company that plans to use gene editing to spread fortunate DNA variations with “one-time” injections of the gene-editing tool CRISPR.
Heart doctors involved say the DNA-tweaking injections could “confer lifelong protection” against heart disease.
CRISPR genome editing is one of the most significant, world-changing technologies of our era, allowing scientists to make incredibly precise cut n’ paste edits to the DNA of living organisms. Now, one synthetic biologist from NASA plans to make it as accessible as a home science kit, so you can bio-hack yeast and bacteria on your kitchen bench.