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How does a star’s activity influence exoplanet data obtained by scientists? This is what a recent study published in The Astrophysical Journal Supplement Series hopes to address as a team of researchers at University College London (UCL) investigated how stellar activity, specifically star spots, could be “contaminating” exoplanet data, specifically exoplanet atmospheric data. This study has the potential to help astronomers develop more efficient methods for studying exoplanets and their atmospheres, specifically with the number of confirmed exoplanets increasing regularly.

For the study, the researchers used NASA’s Hubble Space Telescope to analyze data from 20 gas giant exoplanets ranging in size between Neptune-like and hot-Jupiter that transited their respective parent stars. To obtain a more complete dataset, the team observed the exoplanets from optical to near-infrared wavelengths. In the end, they discovered a broad range of “stellar contamination”, meaning stellar activity was influencing the exoplanet data, specifically regarding the atmospheric compositions and temperatures. For example, the results indicated that the number of specific molecules had errors as high as 6 orders of magnitude while temperatures had errors as high as 145 percent.

“Hotter, brighter regions (faculae) emit more light and so, for instance, if a planet passes in front of the hottest part of the star, this might lead researchers to over-estimate how large the planet is, as it will seem to block out more of the star’s light, or they might infer the planet is hotter than it is or has a denser atmosphere. The reverse is true if the planet passes in front of a cold starspot, making the planet appear ‘smaller’,” said Alexandra (Alex) Thompson, who is a PhD student in UCL’s Department of Physics & Astronomy and a co-author on the study.

Musa, A., Khan, S., Mujahid, M. et al. The shallow cognitive map hypothesis: A hippocampal framework for thought disorder in schizophrenia. Schizophr 8, 34 (2022). https://doi.org/10.1038/s41537-022-00247-7

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Topical ABT-263 effectively reduced several senescence markers in aged skin, preparing it for improved wound healing. Researchers from Boston University’s School of Medicine have identified a promising treatment that could improve wound healing in aging skin. Their study, published in the journal Aging, reveals that the drug ABT-263 can significantly accelerate skin repair by eliminating old, damaged cells known as senescent cells.

From the press release.

Cyclarity Therapeutics is pleased to announce regulatory approval to begin its first-in-human clinical trial. The trial will be conducted at CMAX, one of Australia’s leading clinical research centers, in partnership with Monash University. This effort will be led by Dr. Stephen Nicholls of the Victorian Heart Institute (VHI), a distinguished leader in cardiovascular medicine. In addition to a traditional SAD/MAD phase 1 trial, the authorization includes an allowance to enroll 12 patients with Acute Coronary Syndrome (ACS) to assess the safety of UDP-003 in individuals with plaque buildup, as well as to explore anecdotal evidence of efficacy. This represents a critical first step in evaluating the potential impact of our therapy in a population with high unmet need.

The distinct population of endothelial cells that line blood vessels in the insulin-producing “islets” of the human pancreas have been notoriously difficult to study, but Weill Cornell Medicine investigators have now succeeded in comprehensively detailing the unique characteristics of these cells.

The resulting atlas advances basic research on the biology of the pancreas and could lead to new treatment strategies for diabetes and other pancreatic diseases.

In the study, published in Nature Communications, the researchers devised a set of methods for rapidly isolating and profiling endothelial cells called ISECs (islet-specific endothelial cells) from donor pancreases.

Vimentin is a type III intermediate filament (IF) protein normally expressed in cells that develop into connective tissue, blood vessels, and lymphatic tissue (mesenchymal cells). Despite being widely studied, its role in tumor growth and progression remains unexplored.

A team of researchers at Queen Mary University of London have discovered how a small change in the vimentin protein can make more aggressive. The work is published in the journal eLife.

By modifying a specific amino acid cysteine to serine residue at position 328 in vimentin, they discovered that this mutation disrupted the protein’s interaction with the cell’s structural network. Remarkably, the mutated vimentin induced aggressive cancer-like behavior in breast cancer cells, including faster cell growth, migration, and invasion accompanied by reduced .

The first of the studies, carried out by Meta’s Fundamental Artificial Intelligence Research (FAIR) lab in Paris, collaborating with the Basque Center on Cognition, Brain and Language in San Sebastian, Spain, demonstrates the ability to decode the production of sentences from non-invasive brain recordings. Using magnetoencephalography (MEG) and electroencephalography (EEG), researchers recorded brain activity from 35 healthy volunteers as they typed sentences.

In today’s episode, William Hahn explores how Wolfram’s universal computation and Leibniz’s layered consciousness might converge in modern AI, potentially yielding a new evolutionary step in machine self-awareness.

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