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Protracted Fate Acquisition and Epigenetic De‐Aging During Induced Neural Stem Cell Conversion of Human Blood Cells

Rejuvenation breakthrough: Scientists reverse 60 years of aging in human cells.

Turning Back the Biological Clock.

Scientists have long searched for ways to transform ordinary human blood cells into specialized brain stem cells. A major breakthrough in this field is direct conversion—a technique that rewires blood cells directly into induced neural stem cells (iNSCs) using specific cellular master switches (‘SOX2‘ and ‘cMYC‘), completely bypassing the complex embryonic-like pluripotent stage. While researchers knew this process seemed to “wash away” biological aging, key questions remained: How fast does this rejuvenation actually happen, and how completely do these new brain stem cells shed their past?

Key findings: a slow and steady rejuvenation.

To find out, researchers took blood cells from donors across an extraordinary age spectrum—from newborns all the way to a 101-year-old—and turned them into iNSCs. Using epigenetic “aging clock” algorithms that estimate biological age based on DNA modifications, they tracked the transformation over time.

* Dramatic Age Reversal: The blood cells underwent massive epigenetic de-aging. Early-stage converted cells retained only about 13% of the original donor’s age, and as the cells continued to divide, that number dropped to just 5%. A 101-year-old’s blood cell effectively became biologically “young.”

* A Protracted Process: Rejuvenation wasn’t an instant switch. The process unfolded gradually over several weeks—even when cell division was intentionally paused.

From Prompt to Walking Robot With NVIDIA RTX Spark

AI agents on NVIDIA RTX Spark help developers turn ideas into real-world robots. Astra connects FreeCAD, Blender, and SimReady Foundation to create assets and build training environments in NVIDIA Isaac Sim.

NVIDIA Omniverse RTX and Newton bring perception and physics together, while reinforcement learning in NVIDIA Isaac Lab trains Micro Duck to navigate obstacles. After training in the cloud, its policy is validated in Isaac Sim on RTX Spark, bringing its learned skills from simulation into the real world.

🔗 Explore NVIDIA RTX Spark → https://www.nvidia.com/en-us/products… #NVIDIARTX #Robotics.

#PhysicalAI #NVIDIARTX #Robotics

The Human Brain Turned Out to Be Two Separate Organs

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Hello and welcome! My name is Anton and in this video, we will talk about the origin of two humans brains.
Links:
https://med.stanford.edu/news/all-new…
Previous video: • Lab-Grown Human Brain Cells Can Sense Time…
#human #brain #neuroscience.

0:00 Human brain discoveries.
0:50 Not just one organ?!
2:15 How brain initially develops.
3:00 Two different lineages and genes.
4:35 Experiments show even more.
5:35 Implications for neuroscience.
7:10 Ancient evolutionary history.
8:30 Brain atlas confirms 3000+ types of neurons.
9:55 Why is our brain so large? HARs.
11:35 Why this matters for the medical fields.
14:05 Conclusions.

Enjoy and please subscribe.

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“Reversing Human Aging” — Dr. Michael Fossel and “Update on Age Reversal” — Bill Faloon — Oct 22nd

Dr. Fossel is a recognized expert in aging and telomere biology, He has authored over 100 scientific articles, book chapters, and books, and has lectured internationally, including at the National Institutes of Health. Fossel will give a presentation on Age Reversal AND also have a book signing afterwards!

Bill Faloon, Founder of Perpetual LIfe will give us an Update on Age Reversal!

Celebrate Halloween with a Costume Party and Buffet after the event!

PerturbAI and OpenAI Unveil First-of-Its-Kind AI Reasoning Agents to Scale Biomedical Discovery

PerturbAI in cooperation with Open AI are doing amazing brain biology discovery work with 2,000 agents.

#ArtificialIntelligence #neuroscience


- Thousands of AI agents work in parallel to interpret experimental data, connect findings with scientific literature, and identify promising hypotheses for scientists to test

- Agents analyzed PerturbAI’s whole-brain genomic dataset and synthesized insights in just 32 minutes, compared with an estimated months to a year of serial human analysis and literature review

- The work builds on a year-long collaboration that is now expanding into joint drug-target discovery, leveraging PerturbAI’s proprietary causal biological data to accelerate science and medicine.

Consciousness research is ready for its Einstein moment

It remains a mystery about how consciousness relates to neural mechanisms. Now, with the advent of AI, some argue that consciousness could emerge in these systems. Here, philosopher and Lead for Responsible AI at Microsoft Ken Archer, and phenomenologist Harald Wiltsche, argue that the attempt to reduce consciousness to a mechanism won’t work and relies on a misunderstanding. Instead, using Einstein’s re-thinking of the ether as a guide, we can unlock the mystery of consciousness.

The strongest argument for believing that AI can become humanly intelligent, or even conscious, seems to come from science. Neuroscience, we are told, is steadily revealing—or will reveal, given enough time—that intelligence and consciousness are nothing more than what the brain’s neural mechanism does. Evolution appears to make the conclusion unavoidable. Matter existed for billions of years before intelligent and conscious beings appeared. Conscious intelligence emerged from that matter through natural processes. So intelligence and consciousness must ultimately be reducible to particular organizations of matter, which neuroscience tells us is a particular organization of neurons.

To resist the reducibility of intelligence and consciousness to some type of organization of matter can sound like resisting science itself. Perhaps consciousness seems irreducible only because we do not yet understand the mechanism. Give neuroscience another century and the mystery will disappear, just as so many earlier mysteries disappeared before it. With the ability to do neuroscience-like experiments on AI neural networks—known as mechanistic interpretability—perhaps the mystery will disappear even sooner.