Dr. Adam Salmon, Associate Director of the Barshop Institute at UT Health San Antonio, reveals historic findings from the first long-term rapamycin trial in non-human primates. Discover how daily mTOR inhibition extends marmoset median lifespan by 10% to 15%, preserves kidney function, and why primate glucose metabolism responds differently to rapamycin than rodents.

For deeper breakdowns of emerging longevity trials and key takeaways from our expert interviews, subscribe to the Modern Healthspan Briefing: https://modernhealthspan.substack.com… Support Cellular Energy & Mitochondrial Health: Optimize your metabolic pathways with Renue By Science Liposomal NAD+, GlyNAC, and longevity formulas: 👉 (10% off: MHS) https://tinyurl.com/bdew4bfs — NMN Powder • Lipo NR • Spermidine 🧬 SUPPORT THE CHANNEL & LONGEVITY PARTNERS If you would like to support our channel please consider joining our Patreon: / modernhealthspan Seeking Health (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ — Zinc Picolinate • Optimal D3+K2 Stemregen (15% off: MODERN) US only https://tinyurl.com/45z968yr AX3 Life (20% off: MODERN20) https://ax3.life/MODERN20 — Astaxanthin n1o1 (10% off: Modern) https://tidd.ly/3IczGRW — Nitric Oxide Lozenges Qualia (15% off: MODERN) Creatine+ https://tinyurl.com/mr3z35jd • Senolytic https://bit.ly/4jlaibe Wellness Extract (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE — Geranylgeraniol • Vit E 00:00 — Why Marmosets Are the Ideal Primate Model for Aging 05:35 — Landmark Marmoset Trial: Lifespan Extended 10–15% 08:45 — Healthspan Protection: Kidney Function & Oral Health 11:17 — Dosing Strategy: Daily vs. Intermittent Protocols 13:09 — The Glucose Paradox: Blood Sugar in Primates vs. Mice 16:02 — mTORC1 vs. mTORC2: Why Mouse Liver Differs from Humans 18:40 — The Case for Pulsed Dosing & Autophagy Cycling 20:43 — Unexpected Side Effects: Marmoset Joint & Bone Data 22:46 — Cross-Species Hit Rate: Translating Mice to Humans 26:40 — Biomarkers, Metabolic Resilience & Primate Lifespan 29:07 — Primate Research Infrastructure & Nathan Shock Center 32:03 — Dismantling the Free Radical Theory of Aging 35:52 — Immune Resilience & Barshop Institute Next Steps 39:45 — Reversing Side Effects & Next-Gen mTORC1 Inhibitors 43:38 — Can AI Replace Non-Human Primate Aging Models? Can rapamycin safely slow biological aging and extend lifespan in primates? While rapamycin consistently extends mouse lifespan in the NIA’s Interventions Testing Program (ITP), key questions remained regarding primate biology and metabolic safety. Dr. Adam Salmon discusses his landmark trial in common marmosets, demonstrating a 10% to 15% increase in median survival, mirroring early mouse longevity trials. Dr. Salmon breaks down the healthspan benefits observed in these primates, including preserved kidney function, delayed oral disease, and joint protection. He unpacks metabolic differences between rodents and primates, detailing how human liver physiology differs in glucose regulation, the mechanism behind mTORC1 versus mTORC2 inhibition, and why transient metabolic side effects reverse rapidly within one week of treatment cessation. Additionally, Dr. Salmon shares insights on the Free Radical Theory of Aging and mitochondrial resilience. If you would like to support our channel please consider joining our Patreon: / modernhealthspan 🔬 Scientific Citations & References Mentioned: 1. Salmon, A.B. et al. Long-term treatment with the mTOR inhibitor rapamycin extends lifespan and improves healthspan in common marmosets. Landmark Primate Trial / Barshop Institute. 2. Lamming, D.W., Salmon, A.B. et al. (2012). Depletion of mTOR and mLST8 uncouples longevity from rapamycin-induced changes in glucose homeostasis. Science, 335(6076): 1638–1643. PMID: 22,461,615 3. Marolf, B.A., Salmon, A.B. et al. (2024). Impact of long-term rapamycin treatment on age-related osteoarthritis in common marmoset. bioRxiv, DOI: 10.1101/2024.05.14.594256 4. Bene, M. & Salmon, A.B. (2023). Lifespan-extending compound interventions across laboratory animal model species. GeroScience, 45: 2153–2171. PMID: 36,780,031 5. Horvath, S., Salmon, A.B. et al. (2021). DNA methylation age analysis of rapamycin in common marmosets. GeroScience, 43: 2419–2428. PMID: 34,626,308 🌐 Connect with Dr. Adam Salmon: • Barshop Institute: https://barshop.uthscsa.edu • Faculty Profile: https://uthscsa.edu/medicine/faculty/.… ⚠️ Medical Disclaimer: Modern Healthspan content is for educational and informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a qualified physician or healthcare provider before making changes to your health regimen, diet, or lifestyle. #Rapamycin #Longevity #Healthspan.

⚡ Support Cellular Energy & Mitochondrial Health:
Optimize your metabolic pathways with Renue By Science Liposomal NAD+, GlyNAC, and longevity formulas:
👉 (10% off: MHS) https://tinyurl.com/bdew4bfs — NMN Powder • Lipo NR • Spermidine.

🧬 SUPPORT THE CHANNEL & LONGEVITY PARTNERS
If you would like to support our channel please consider joining our Patreon: / modernhealthspan.

Seeking Health (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ — Zinc Picolinate • Optimal D3+K2
Stemregen (15% off: MODERN) US only https://tinyurl.com/45z968yr.
AX3 Life (20% off: MODERN20) https://ax3.life/MODERN20 — Astaxanthin.
n1o1 (10% off: Modern) https://tidd.ly/3IczGRW — Nitric Oxide Lozenges.
Qualia (15% off: MODERN) Creatine+ https://tinyurl.com/mr3z35jd • Senolytic https://bit.ly/4jlaibe.
Wellness Extract (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE — Geranylgeraniol • Vit E

00:00 — Why Marmosets Are the Ideal Primate Model for Aging.
05:35 — Landmark Marmoset Trial: Lifespan Extended 10–15%
08:45 — Healthspan Protection: Kidney Function & Oral Health.
11:17 — Dosing Strategy: Daily vs. Intermittent Protocols.
13:09 — The Glucose Paradox: Blood Sugar in Primates vs. Mice.
16:02 — mTORC1 vs. mTORC2: Why Mouse Liver Differs from Humans.
18:40 — The Case for Pulsed Dosing & Autophagy Cycling.
20:43 — Unexpected Side Effects: Marmoset Joint & Bone Data.
22:46 — Cross-Species Hit Rate: Translating Mice to Humans.
26:40 — Biomarkers, Metabolic Resilience & Primate Lifespan.
29:07 — Primate Research Infrastructure & Nathan Shock Center.
32:03 — Dismantling the Free Radical Theory of Aging.
35:52 — Immune Resilience & Barshop Institute Next Steps.
39:45 — Reversing Side Effects & Next-Gen mTORC1 Inhibitors.
43:38 — Can AI Replace Non-Human Primate Aging Models?