Polyamines may protect cells from toxic iron buildup by keeping reactive iron under control.

Iron keeps cells alive, but when too much of it remains chemically reactive, the same metal can become destructive. Excess free iron can drive reactions that damage DNA, proteins, and cell membranes, creating a problem cells must constantly control.

Whitehead Institute Member Ankur Jain, former postdoc Whitney Henry, and graduate student Pushkal Sharma have identified an unexpected part of that protective system: small molecules known as polyamines.