New research from an expert in cancer biology explains what triggers liposarcoma cells to become more or less aggressive and identifies potential targets that could keep aggressive tumors in check. A study led by Blake Wilde, Ph.D., of Roswell Park Comprehensive Cancer Center highlights how this discovery may pave the way for new treatment options for this cancer.

The findings are published in the journal Science Advances.

More than half of all people with liposarcoma will see their cancer return after treatment, underscoring the need for new and better treatment options. The two most common types of this cancer, which begins in fat tissue, are well-differentiated (WD) and dedifferentiated (DD) liposarcoma, explains the study’s first author, Blake Wilde, Ph.D., assistant professor of oncology in the Departments of Urology and Cell Stress Biology at Roswell Park.