Every time a cell divides, it must accurately copy and distribute its DNA between two new cells. However, in some cases, chromosomes do not fully separate, leaving behind thin strands of DNA known as DNA bridges that connect the two newly formed cells.

These fragile structures can be vulnerable to damage and, if not properly managed, can have severe consequences for genome stability. Researchers from King’s, in collaboration with research teams at the University of Utah and biotechnology company Altos Labs, have now revealed how cells protect themselves from this threat.

Published in Nature Structural & Molecular Biology, the study shows that ESCRT-III proteins, previously known for helping cells reshape and repair membranes, have an unexpected role in protecting DNA bridges during cell division.