An interesting paper: Kul et al. engineered adenovirus serotype 5 (Ad5) to bear alternate fiber knobs which enabled cerebellum transduction, primarily via the hCD46 receptor in a humanized mouse model. Adenoviruses were injected directly into the mice’s brains at surgically defined locations.

Young and colleagues developed a novel adenovirus vector that transduces Purkinje cells in a humanized mouse model. Since commonly used adenovirus vectors do not transduce Purkinje cells, these vectors offer immense promise toward developing gene therapy approaches for cerebellar disorders and potentially other neurological disorders requiring expression of large transgenes.