In a promising sign for the potential of focused sound waves to improve care for brain tumors, UVA Health researchers have determined that tumors called gliomas may be even more receptive to targeted drug delivery than normal brain tissue.

While the research is still in its early stages, the findings help allay concerns that brain tumors might have properties that would make them stubbornly resistant to the cutting-edge approach. The UVA scientists are using tiny “microbubbles” that are activated by sound waves to open the brain’s natural protective barrier, known as the “blood-brain barrier,” so that drugs can enter exactly where needed.

Inside brain tumors, cancer cells mutate the structure of the blood-brain barrier and its function becomes unpredictable. In turn, this raises questions about how effectively focused ultrasound can deliver therapies in the brain tumor environment and what sizes of drug molecules can be delivered most effectively. The new research from UVA Health’s Focused Ultrasound Cancer Immunotherapy Center provides important insights on both fronts.