Nanoporous material-based separation technology is vital in many applications because it can precisely distinguish between and separate nearly identical chemical or biochemical molecules.

Previous research by Professor Susumu Kitagawa of Kyoto University’s Institute for Integrated Cell-Material Sciences (WPI-iCeMS) and colleagues, published in Nature, applied this technology to separate two very similar types of water molecules—regular water (H₂O) and heavy water (D₂O), which have similar overall properties but slightly different masses. But the underlying mechanisms of that separation were not well understood.

Now, a study led by Professor Shinji Saito of the Institute for Molecular Science (IMS) in Japan and published in Nature Communications in July has provided a theoretical explanation for that phenomenon, using H₂O and D₂O molecules to study nanopore behavior in a metal-organic framework.