Scientists at the University of Oklahoma have identified a previously unrecognized immune system pathway that helps explain how cigarette smoking increases the risk of cardiovascular disease. The findings, published in Circulation Research, show that cigarette smoke activates immune cells that trigger widespread inflammation throughout the body, accelerating the buildup of plaque in arteries.

Cigarette smoking is a major risk factor for cardiovascular disease and is linked to heart attacks, strokes and other life-threatening conditions. While smoking’s harmful effects on the lungs are well established, the biological processes that connect cigarette smoke exposure to cardiovascular disease have been less well understood.