BACKGROUND: SIRT1 (sirtuin 1), a nicotinamide adenine dinucleotide–dependent protein deacetylase.

Regulates cardiovascular inflammation by modulating cellular stress, inhibiting NLRP3.

(NLR family, pyrin domain-containing 3) activation, and promoting the clearance of.

Damaged mitochondria. However, its precise role in the pathogenesis of Kawasaki disease.