Researchers have developed light-transmitting hydrogel fibers that are just hundreds of micrometers in diameter. With further development, these soft fibers could one day make it possible to use imaging techniques to detect early breast cancer hidden inside very small breast ducts.

“While traditional, relatively rigid fiber probes may cause mechanical damage when entering narrow, curved or soft tissue spaces, our fibers are very soft with mechanical properties more similar to those of human soft tissues,” said research team leader Yu Zhang from Harbin Engineering University in China. “We made these fibers using a draw-spinning method that was inspired by spider-silk spinning.”

In research appearing in Optics Express, the researchers describe how they tested the new hydrogel fibers by incorporating them into an imaging system and using it to analyze standard pathology-stained breast tissue sections. The imaging system successfully reconstructed the microscopic features used by pathologists to evaluate tumors and, when combined with artificial intelligence algorithms, distinguished tumor subtypes with an accuracy of 93.97%.