Microglial lysosomes immune activation and protein turnover.

In addition to its role in protein and organelle homeostasis, lysosomes are also involved in nutrient sensing, cell metabolism, immune response, and programmed cell death.

Lysosomes are heterogeneous subpopulations and their dysfunction has been associated with the pathogenesis of several neurodegenerative diseases.

Although lysosomal biogenesis, transport, and heterogeneity are well studied in neurons, the researchers in this review discuss microglial lysosome biology its regulation, composition, and function, and how these properties are linked to immune activation, aging, and certain disease pathologies. sciencenewshighlights Science Mission https://sciencemission.com/microglial-lysosomes

Npj Dementia — “Micro-managing” immune activation and protein turnover: microglial lysosomes in the context of health and disease. npj Dement. 2, 35 (2026). https://doi.org/10.1038/s44400-026-00086-8