New in JBC press.

Lipotoxicity caused β-cell mass decrease and impaired β-cell function in type 2 diabetes mellitus (T2DM). We previously reported that caveolin-1 (Cav-1) deficiency protected pancreatic β cells against palmitate (PA)-induced apoptosis and dysfunction in both NIT-1 cells and isolated islets. In this study, we firstly established inducible β-cell-specific Cav-1 knockout (iβ-Cav1 KO) mice model. Next, we investigated whether Cav-1 depletion in vitro or in vivo affected β-cell function and survival through the regulation of autophagy under lipotoxicity.