In three RCTs, Tirzepatide was associated with clinically meaningful weight loss among adults with overweight or obesity, even when concomitant weight-inducing medications were initiated during treatment.

Question What is the association between tirzepatide and weight reduction among patients with overweight or obesity who initiated concomitant weight-inducing medications?

Findings In this post hoc analysis of participants in the SURMOUNT-1,-3, and-4 trials receiving at least 1 concomitant weight-inducing medication (17.3%-20.0%), tirzepatide treatment was associated with comparable weight loss to the primary study results.