David B. Frank & team now report BRD4 regulates gene expression and cell differentiation of lung endodermal progenitors into epithelial cells of the lung airways:
The figure shows mutant lungs exhibit fewer and dilated airways with diminished SOX2 expression in distal airways in addition to the formation of cystic distal airway structures.
1Department of Pediatrics, Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, and.
2CHOP Cardiovascular Institute, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
3Penn Cardiovascular Institute.
4Penn-CHOP Lung Biology Institute, and.