https://doi.org/10.1172/jci.insight.

In this Research article, Benjamin D. Philpot & team establish a multimodal dual-reporter mouse that accelerates AngelmanSyndrome therapeutic development through scalable cell-based screening, high-resolution whole-brain mapping, non-invasive live imaging, and sorting neurons with unsilenced paternal Ube3a.

²Animal Models Core.

³Department of Genetics, and.

⁴Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.