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Scientists discover on/off gene switches that could revolutionize personalized medicine

Year 2025 This could essentially end disease where the diseases would be edited off and the host repaired internally.


Scientists identified 473 human genes that act as genetic “on/off switches,” shaping disease risk through tissue-specific or universal patterns regulated by DNA changes and hormones.

Study: Switch-like gene expression modulates disease risk. Image Credit: gopixa / Shutterstock.

In a recent article published in Nature Communications, researchers analyzed methylomes, transcriptomes, and genomes from 943 individuals to characterize and identify genes that exhibit distinct on-off switches and explore their epigenetic and genetic regulation.

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