In this cohort study of cognitively unimpaired older women, p-tau217 was associated with incident MCI or dementia up to 25 years later.

This cohort study examines associations of baseline plasma phosphorylated tau 217 with incident mild cognitive impairment (MCI) or dementia and whether associations vary by age, race, APOE ε4 carrier status, or hormone therapy use among older men and women.