Barbara J. Vilen & team now identify defective late endosomes and lysosomes (LELs) in patients with active lupus and show reduced LEL function promotes SLE through chronic PI3k activity and SHP-1/SHIP-1 defects:
The figure shows bone marrow-derived macrophages from lupus prone mice (MRL/lpr) have decreased recruitment of pSHIP-1Y1022 (green) to the plasma membrane, indicated by cholera toxin-stained lipid rafts (blue), compared with control mice (B6).
1Department of Microbiology and Immunology and.
2Division of Rheumatology, Allergy, and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina, USA.
3Division of Rheumatology and Immunology, Duke University Medical Center, Durham, North Carolina, USA.