New work from Chaorui Duan, William Fairbrother et al. (Brown University) reveals how intronic Alu repeats and RNA metabolism shape endogenous dsRNA levels and cell-intrinsic immunity.

InnateImmunity Inflammation

Defective intron recycling leads to the accumulation of intron-derived double-stranded RNA in the cytoplasm, which suppresses PKR and RNase L activation.