Full talk at Future Day 2026 — link in reply 🔗
Polymath and trailblazer in bio-rejuvenation Aubrey de Grey gave a talk at Future Day 2026 on the next phase of robust mouse rejuvenation trials!
Synopsis: The “damage repair” approach to bringing aging under medical control has made huge strides since I first proposed it 25 years ago. However, since it is a divide-and-conquer strategy, we should not be surprised at the absence of progress in the “bottom line” of life extension, even in mice. Can we realistically expect that to change any time soon? I will present reasons to believe that we can, in the form of accelerating progress in proofs of efficacy of individual treatments, together with initial proof of concept that combining damage repair modalities will give additive benefits.
0:00 Intro.
0:29 Talk starts.
1:28 Age related vs infectious diseases.
3:26Epidemic of the chronic conditions of late life — why?
4:42 Ways to be sick: popular view.
7:10 Aging in three words (metabolism, damage, pathology)
11:46 Ways to be sick: correct view.
15:29 What we do these days against aging — Geriatrics.
18:21 Gerontology: A more promising approach?
20:57 Metabolism is complex.
22:37 Maintenance: A common sense alternative.
24:39 Comparison: car maintenance.
26:00 7 deadly things.
29:17 Cell 153:1194 — too many citations to count.
30:22 The first round of the race to RMR (Robust Mouse Rejuvenation)
38:43 Females: yay, additivity!
40:09 Males: messier, but mostly the same story.
41:02 What health indices did we measure?
43:23 RMR2: ASAP! See levf.org/rmr2
46:30 AUBRAI
48:36 Learn more and help!
51:11 How has the longevity industry vibe changed over the last 7 years?
56:32 LEV Foundation only org working on this combination of damage repair regimes.
57:55 Has AI made progress in helping solve aging? In-silico medicine.
1:01:16 Changes to seven deadly things?
1:04:54 Hallmarks of aging — defacto taxonomy — difficulty translating to other taxonomies?
1:06:17 Has the damage repair methodology been attracting people over?
1:09:56 Stradelling both academia and private industry — but what about the state?
1:13:36 Robust Mouse Rejuvenation timelines under ideal funding.
1:19:49 Infections.
1:25:46 Treatment cadence.
#rejuvenation #medicine #health #aging #ageing.
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Adam Ford.
Science, Technology & the Future — #SciFuture — http://scifuture.org