In this Research Article, Ruxandra Bachmann-Gagescu & team integrate blood and urine biochemistry with genetics to improve interpretation of genetic findings in adults with kidney stone disease—the approach has prognostic value, enabling personalized risk assessment.

³Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

⁴National Center of Competence in Research (NCCR) Kidney. CH, Bern, Switzerland.

⁵Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.