Here, Fanghui Lu & team report OLIG2, a master transcription factor in glioblastoma stem cells, enables immune evasion by suppressing CXCL10. And, targeting OLIG2 overcomes immunotherapy resistance and improves survival.
1Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
2Department of Neurosurgery, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
3School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.