https://doi.org/10.1172/JCI195189 Dolores Hambardzumyan & team develop mouse models of germline and somatic MMR-deficient high-grade gliomas, finding a role for MMR genes in tumor growth and temozolomide resistance, and presenting KL-50 as a therapeutic avenue.
The figure demonstrates a potent anti-tumor effect from KL-50 treatment in glioblastoma models.
1Departments of Oncological Sciences and Neurosurgery, The Tisch Cancer Institute and.
2Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
3Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, New York, USA.