Danièle Stalder, Conceição Pereira, David C. Gershlick et al. (University of Cambridge) uncover new regulators of Golgi-to-plasma membrane transport, showing that a PTPN23-dependent ESCRT pathway is essential for secretion of membrane & soluble cargoes, including hormones & antibodies.

Stalder and Pereira et al. combine affinity isolation of post-Golgi carriers, mass spectrometry, and a pooled CRISPR-KO screen to uncover new regulators of.