Kostas Pantopoulos & team find mice that lack IRP1 have altered energy metabolism and are protected against metabolic syndrome pathologies:
The figure shows liver in Irp1-/- mice fed a high-fat diet have reduced fat content; stained with oil red O. MetabolicSyndrome.
1Lady Davis Institute for Medical Research, Jewish General Hospital and Department of Medicine, McGill University, Montreal, Quebec, Canada.
2Department of Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa, Ontario, Canada.
3Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, Canada.