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Abstract: Over 100 years ago, platelets were observed to interact with neutrophils in a blood clot

Eric Boilard & team now detail platelet-neutrophil interactions as being more abundant in arthritic mice than in healthy mice, reporting neutrophils migrate in tissue to play a pathogenic role in autoimmune arthritis and noting that they fail to migrate in the absence of platelets:

Image credit: Emma Bourgeault (emmabourgeault).


1Faculté de Médecine de l’Université Laval, Université Laval, Québec City, Québec, Canada.

2Centre de Recherche ARThrite – Arthrite, Recherche, Traitements, Université Laval, Québec City, Québec, Canada.

3Axe maladies infectieuses et immunitaires du Centre de recherche du Centre hospitalier universitaire de Québec-Université Laval, Québec City, Québec, Canada.

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