Amy B. Heimberger find therapeutic benefit in adding the STING agonist 8,803 to radiation in preclinical models of glioma. The combination reprogramed the glioma tumor microenvironment, and 8,803 induced the opening of the blood-brain barrier.

³Department of Radiology.

⁴Department of Neurology, and.

⁵Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.