Dana T. Graves & team identify the CD137L/CD137 axis as a pivotal mediator of diabetes-induced inflammatory tissue destruction, in which dendritic cell produced CD137L activates γδ T-cells through CD137, leading to a dysregulated host response and worsening damage from bacterial challenge:
The figure shows microCT images of 3D reconstruction of the molar teeth from mouse models of periodontitis injected with control, CD137L-agonist, CD137L-antagonist antibodies.
1Hospital of Stomatology, Guanghua School of Stomatology and.
2Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China.
3Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.