Here, Elizabeth P. Henske report mTORC1 hyperactivation in cystic lungs from patients and validate its role in lung cyst formation using a novel pre-clinical model:
The figure shows lung mesenchymal and epithelial cell differentiation.
1Division of Pulmonary, Critical Care and Sleep Medicine; Department of Internal Medicine; University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
2The Saban Research Institute, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
3Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.