A research team from the Kunming Institute of Zoology (KIZ) of the Chinese Academy of Sciences has demonstrated for the first time in non-human primates that auditory stimulation at 40 Hz significantly elevates β-amyloid levels in the cerebrospinal fluid (CSF) of aged rhesus monkeys, with this effect persisting for over five weeks.

The study, published in the Proceedings of the National Academy of Sciences on January 5, provides the first non-human primate experimental evidence supporting the use of 40-Hz stimulation as a noninvasive physical therapy for Alzheimer’s disease (AD), revealing significant differences between primate and rodent models.