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Simulations predict antibody drug viscosity, paving way for easier self-injection

Monoclonal antibodies (mAbs) aid the body against autoimmune diseases and cancer, among other things. Patients have to pick up the medicine every few weeks. It would be easier for them to be able to inject the medicine themselves at home, but this would only be possible if the medications were highly concentrated but not too viscous.

A team at Ruhr University Bochum, Germany, led by Professor Lars Schäfer from the Center for Theoretical Chemistry and the company Boehringer Ingelheim Pharma have developed a quick and realistic simulation method to make this possible. This method can predict how formulations will behave.

The team reports its findings in the Journal of Physical Chemistry.

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