Prescriptions for the new non-opioid pain medication suzetrigine more than doubled between April and August 2025, according to analysis from Epic Research. The increase indicates a growing interest in opioid alternatives for acute pain, even as clinicians grapple with how and where the drug best fits in practice.

Despite a surge in prescriptions for the non-opioid pain drug suzetrigine, clinicians are still sorting out who benefits the most and when.