Researchers at Istituto Italiano di Tecnologia (IIT-Italian Institute of Technology) have developed an innovative microscopy technique capable of improving the observation of living cells. The study, published in Optics Letters, paves the way for a more in-depth analysis of numerous biological processes without the need for contrast agents. The next step will be to enhance this technique using artificial intelligence, opening the door to a new generation of optical microscopy methods capable of combining direct imaging with innovative molecular information.

The study was conducted under the guidance of Alberto Diaspro, Research Director of the Nanoscopy Unit and Scientific Director of the Italian Nikon Imaging Center at IIT, by Nicolò Incardona (first author) and Paolo Bianchini.