Katherine Y. King & team now identify epigenetic changes in hematopoietic stem and progenitor cells in a mycobacterial infection model that are retained in downstream macrophages, providing mechanistic mediators of innate immune memory and explaining persistence of central trained immunity.
1Graduate Program in Cancer and Cell Biology.
2Department of Pediatrics, Division of Infectious Disease, Texas Children’s Hospital and Baylor College of Medicine.
3Stem Cells and Regenerative Medicine Center.
4Department of Molecular and Human Genetics.