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DNA-Protein Crosslinks Explain Accelerated Aging in Progeria

In Ruijs-Aalfs progeria syndrome, patients experience accelerated aging and liver cancer.

Now, scientists showed that mutations in a certain gene prevent cells from repairing DNA damage during mitosis, triggering inflammatory immune responses that may fuel premature aging.

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Researchers have shown that harmful bonds between protein and DNA fuel immune attack in progeria. Pumping up a protein that cuts these bonds could prevent symptoms.

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