Nutritional strategy to prevent immune-mediated damage.

Excessive immune response with the inflammatory cytokine and chemokine production may lead to tissue damage.

With Yersinia pseudotuberculosis infection in mic, the researchers found that dietary methionine enhances kidney filtration and promotes urinary excretion of inflammatory cytokines during infection and protects against anorexia, wasting, blood-brain barrier dysfunction, and lethality.

Mechanistically, methionine and its metabolite S-adenosyl methionine (SAM) activate renal mTORC1 signaling, promoting renal growth and enhanced glomerular filtration function.

By improving cytokine clearance, this pathway mitigates immune-mediated damage and reveals a nutritional strategy to promote cooperative defenses. sciencenewshighlights ScienceMission https://sciencemission.com/Dietary-methionine

Troha et al. found that dietary methionine enhances kidney filtration and promotes urinary excretion of inflammatory cytokines during infection. By improving cytokine clearance, this pathway mitigates immune-mediated damage and reveals a nutritional strategy to promote cooperative defenses.